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WELCOME
This newsletter includes recent news and information from NanoString Technologies and our community.
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NanoString Technologies Launches Early-Access Program for CNV Custom Assays
At the European Society for Human Genetics meeting in June, we announced the early access program for our new nCounter Custom Copy Number Variation Assays and are now accepting applications! Read More 
NanoString Receives ISO 13485:2003 Certification
In May, we received ISO 13485:2003 certification, an internationally recognized quality standard for medical devices. This was an important milestone in our strategy to develop the nCounter Analysis System for molecular diagnostics. Read More
Human microRNA Expression Assay Kit Launched at AACR
At the American Association for Cancer Research annual meeting in April we launched a unique new product for miRNA analysis that includes a multiplexed assay for profiling the human miRNA transcriptome in a single tube. NanoString's Human miRNA Expression Assay Kit enables researchers to profile more than 700 human and human-viral miRNAs with specificity and sensitivity comparable to qPCR at a fraction of the cost. Read More
In the News
Genetic Engineering & Biotechnology News (GEN) recently featured the nCounter Analysis System and how it is advancing science. Read More
PCR Insider (GenomeWeb) highlighted our early-access program for the new Custom CNV Assays and interviewed users in Steve McCarroll's lab at Harvard/Broad about the technology. Read More (subscription required)
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Human miRNA Expression Assay Kit
The nCounter Human miRNA Expression Assay Kit contains a comprehensive collection of more than 700 human and human-associated viral miRNAs derived from miRBase. The off-the-shelf kits arrive in your lab with the highly multiplexed CodeSet and all of the reagents and consumables necessary to perform the assay. Kits are available in 12, 24, 48, and 96 reactions sizes, offering flexibility and greater access to the technology for labs and projects of all sizes. Read More
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New Webinar: Digital miRNA Expression Analysis
Dr. Sean Ferree presents an introduction to miRNA expression analysis using NanoString's molecular barcodes.
Slides: 27. Duration: 10 minutes. View Webinar
Quick Reference Sheet
This one-page reference sheet allows you to quickly browse available CodeSet panels for miRNA and gene expression analysis. The sheet contains links to easily access additional product information and ordering options.
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Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity
Cell, May 6, 2010
Evelyn Dixit, Steeve Boulant, Yijing Zhang, Amy S.Y. Lee, Charlotte Odendall, Bennett Shum, Nir Hacohen, Zhijian J. Chen, Sean P. Whelan, Marc Fransen, Max L. Nibert, Giulio Superti-Furga, and Jonathan C. Kagan
While mitochondria have emerged as an important site of antiviral signal transduction, a role for peroxisomes in immune defense was unknown. The authors report work involving the use of the nCounter system led to the discovery that the RIG-I-like receptor (RLR) adaptor protein MAVS is located on peroxisomes and mitochondria. The authors describe evidence that peroxisomes are an important site of antiviral signal transduction, which may lead to new therapeutic targets. Read More
Note: We interviewed senior author Jonathan Kagan about this work for our Science nCounter feature in this newsletter.
High accuracy, high-resolution prevalence measurement for the majority of locally expressed regulatory genes in early sea urchin development
Gene Expression Patterns, April 16, 2010
Stefan C. Materna, Jongmin Nama and Eric H. Davidson
Using the nCounter Analysis System, the authors measured the prevalence of 172 transcription factors and signaling molecules in early sea urchin development. These measurements show high fidelity over more than five orders of magnitude down to a few transcripts per embryo. Most of the genes included are locally restricted in their spatial expression, and contribute to the divergent regulatory states of cells in the developing embryo. In order to obtain high-resolution expression profiles from fertilization to late gastrulation samples were collected at hourly intervals. The measured time courses agree well with, and substantially extend, prior relative abundance measurements obtained by quantitative PCR. The data are available via an interactive website for quick plotting of selected time courses. Read More
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NanoString on SelectScience TV!
Check out a video demonstration on SelectScience.tv of the nCounter Analysis System filmed at the 2010 AACR meeting. Watch Now
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SCIENCE nCOUNTER
In this edition of our newsletter we profile a scientist who recently published breakthrough work using the nCounter system in the journal Cell.
Jonathan Kagan, Ph.D., Assistant Professor, Harvard Medical School and Division of Gastroenterology, Children's Hospital Boston
Dr. Kagan and colleagues have discovered an entirely new role for peroxisomes in immune response. Read More
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Have you recently published or presented interesting work using the nCounter Analysis System? Are you planning to? Please let us know and we may feature your work on our website and/or in an upcoming newsletter! Contact Us 
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UPCOMING EVENTS
CHI's Evolution of Next-Gen Sequencing
Providence, RI
September 27-29, 2010
View Details
Join us for a breakfast seminar:
Tuesday, September 28th
7:30-8:00 AM
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Please join our Facebook Group!
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Join our Community for access to:
 Advance notice of special announcements and product updates
Our quarterly newsletter, which features researcher profiles, technical notes and upcoming events
Invitations to exclusive customer activities at conferences and user group meetings
The chance to win an annual $3,000 travel grant award
The opportunity to have your research profiled in our newsletter and other publications
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© 2010 NanoString Technologies, Inc. All rights reserved.
NanoString Technologies, NanoString nCounter, and Molecules That Count are trademarks of NanoString Technologies, Inc., in the United States and/or other countries. All other trademarks and/or service marks not owned by NanoString that appear in this document are the property of their respective owners.
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