Applying high-parameter panels to uncover spatially-resolved candidate biomarkers in clinically relevant tissues

  • 9:00 am (PDT)
Speakers: Joshua J. Rusbuldt, Scientist at Janssen R&D, Oncology Translational Research, Immuno-Oncology and Jason Reeves, PhD, Senior Scientist, Advanced Applications

Biomarker development is a key aspect of many pharmaceutical development pipelines in Oncology during both pre-clinical research as well as clinical development. In addition to traditional methodologies for developing biomarkers, the GeoMx™ Digital Spatial Profiler (DSP) platform offers a new toolkit for exploring and developing candidate biomarker hypotheses from formalin-fixed paraffin-embedded (FFPE) tissues. In this webinar, we will introduce the GeoMx Digital Spatial Profiler, and discuss how the platform ecosystem and content fits into the development cycle for biomarkers. We will highlight validation data demonstrating the ability of this new platform to capture high-plex protein and RNA expression in FFPE tissues from PBMCs, cell lines, and lung cancer samples, demonstrating the concordance with traditional flow cytometry and IHC. We will also discuss analysis of a bladder cancer cohort, which demonstrated the ability of the platform to capture molecular subtyping information, as well as immune contexture from the tumor microenvironment (TME).

The GeoMx Digital Spatial Profiler and related assays are for Research Use Only.  Not for Use in Diagnostic Procedures.