Morphology Driven High-Plex Spatial Analysis of Tissue Microenvironments
A GENEWIZ Webinar Week Presentation
Characterization of the spatial distribution and abundance of proteins and mRNAs with morphological context within tissues enables a better understanding of biological systems in many research areas, including immunology, oncology and neuropathology. Analysis of samples across multiple tumor types and diseases has revealed novel spatially distinct protein and mRNA candidate biomarkers. However, it has proven difficult to perform such studies in a highly multiplexed manner at a throughput scale that is required for translational research programs. To address this unmet need, we have developed a novel platform that can perform high-plex analysis of proteins or mRNAs on a single FFPE section from distinct tissue spatial regions (GeoMxTM Digital Spatial Profiler, DSP). Integrating the GeoMx DSP with either the NanoString nCounter or high-throughput sequencing, hundreds or thousands of spatially resolved analytes can be measured.
FOR RESEARCH USE ONLY. Not for use in diagnostic procedures.