Single-cell spatial transcriptomic mapping of the fallopian tube

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Abstract

The fallopian tube is thought to be the origin of most if not all “ovarian” high-grade serous carcinomas. Understanding the earliest events in fallopian tube carcinogenesis is crucial for early detection and prevention efforts and may also lead to therapeutic insights. Our group has sought to evaluate the benign fallopian tube at the single cell level, using both dissociated normal tissues and spatial transcriptomic mapping (CosMx) of benign fallopian tubes and early/in situ lesions.

Speaker

Brooke Howitt M.D.
Associate Professor of Pathology
Stanford University School of Medicine

Brooke E. Howitt, MD, is an Assistant Professor in the Pathology Department at Stanford University. She received a BA in Biology from Washington University in St. Louis and then obtained her medical degree from Stanford University. Dr. Howitt then completed an Anatomic Pathology residency and the Women’s and Perinatal Pathology Fellowship at Brigham and Women’s Hospital, where she also spent several years as a junior faculty member. It was during her time at Brigham and Women’s Hospital that she worked with Dr. Christopher Crum and developed a keen interest in the role the fallopian tube plays in “ovarian” high-grade serous carcinogenesis. Dr. Howitt is a gynecologic and sarcoma pathologist with academic interests in gynecologic mesenchymal tumors and morphologic and clinical correlates of molecular alterations in gynecologic neoplasia.