Utilizing Spatial Transcriptomics to Unlock Precision Pain Therapeutics

Doloromics is a seed-stage startup developing novel therapeutics to treat chronic pain. The team at Doloromics has built a proprietary computational platform to identify drug targets within the human Dorsal Root Ganglion (DRG). Through a collaboration with NanoString, the company deeply sequenced and transcriptomically profiled nociceptors to uncover moderate-to-low expressed drug targets that would typically be overlooked by traditional sequencing methods. The results demonstrated by the team illuminate the ways in which the GeoMx® Digital Spatial Profiling platform can be used to facilitate an approach to precision medicine.