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3D Biology™ Technology

For Research Use Only. Not for use in diagnostic procedures.

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Helping Your Research

3D Biology is the ability to analyze combinations of RNA and protein simultaneously in a single experiment, from a single sample. 

At NanoString, we are pioneering 3D Biology to accelerate your research and maximize the amount of information that can be generated from a single sample. Based on NanoString’s digital barcode technology and designed for flexibility, NanoString’s 3D Biology™ Technology and the nCounter® Vantage 3D™ portfolio of assays, provides a deeper view of cancer and immune biology and can be mixed and matched to answer a wide variety of biological questions.

  • Quantify both RNA and protein in a single assay to use less precious material and uncover novel insights
  • Simplify your workflow by comparing gene and protein expression for up to 800 targets in a single view
  • Eliminate the potential bias inherent in merging data from different platforms

How it Works

3D Biology Technology is based on digital barcode technology that can measure a variety of nucleic acids, including mRNA and miRNA, with high levels of precision and sensitivity. 3D Biology technology utilizes this core probe design to detect protein using standard NanoString chemistry.

About 3D Biology™
3D Biology™ at Work
About 3D Biology™

NanoString protein analysis leverages antibodies that are barcoded with unique synthetic DNA oligonucleotides for detection of proteins of interest. The DNA oligonucleotide is recognized by a unique reporter probe that contains a fluorescent barcode. Following sample preparation, RNA and protein can all be detected on the nCounter® platform yielding counts of mRNA and protein abundance.

3D Biology™ at Work

Our Vantage 3D Assays are powered by 3D Biology technology and provide solutions across an expanding range of research areas. For more information download our Vantage 3D Brochure.

3D Flow™ Analysis: Seamlessly integrate standard flow cytometry cell sorting with downstream nCounter analysis to interrogate up to 30 proteins and 770 immune-related RNA simultaneously. View details here.

PDX Profiling: Simple and comprehensive profiling to assure that your PDX models are of consistent high quality and that you gain a deeper understanding of the molecular determinants of therapeutic response. View details here.

In the Lab

Advancing Immuno-Oncology with
PanCancer IO 360™ Gene Expression Panel & Services

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Publications

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Identification of a novel immune-inflammatory signature of COVID-19 infections, and evaluation of pharmacokinetics and therapeutic potential of RXn-02, a novel small-molecule derivative of quinolone.

Coronavirus disease 2019 (COVID-19) is a global pandemic and respiratory infection that has enormous damage to human lives and economies. It is caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), a non-pair-stranded positive-sense RNA virus.

Opportunities and Challenges in Understanding Atherosclerosis by Human Biospecimen Studies.

Over the last few years, new high-throughput biotechnologies and bioinformatic methods are revolutionizing our way of deep profiling tissue specimens at the molecular levels. These recent innovations provide opportunities to advance our understanding of atherosclerosis using human lesions aborted during autopsies and cardiac surgeries.

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-tune Virtual Microdissection.

Multiplexing enables the assessment of several markers on the same tissue while providing spatial context. Spatial Omics technologies allow both protein and RNA multiplexing by leveraging photo-cleavable oligo-tagged antibodies and probes, respectively.

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