OLD Category: CosMx SMI

November 1, 2023 / Neuro-oncol adv

  • Moffet JJD, Oluwaseun E Fatunla, Lutz Freytag, Jurgen Kriel, Jordan J Jones, Samuel J Roberts-Thomson, Anna Pavenko, David K Scoville, Liang Zhang, Yan Liang, Andrew P Morokoff, James R Whittle, Saskia Freytag, Sarah A Best
Background: High-grade gliomas (HGG) are aggressive primary brain cancers with poor response to standard regimens, driven by immense heterogeneity. In isocitrate dehydrogenase (IDH) wild-type high-grade glioma (glioblastoma, GBM), increased intra-tumoral…
October 10, 2023 / Cell Rep

  • Tsubosaka A, Komura D, Kakiuchi M, Katoh H, Onoyama T, Yamamoto A, Abe H, Seto Y, Ushiku T, Ishikawa S
The stomach is an important digestive organ with various biological functions. However, because of the complexity of its cellular and glandular composition, its precise cellular biology has yet to be…
October 5, 2023 / Brief Bioinform

  • Tang Z, Liu X, Li Z, Zhang T, Yang B, Su J, Song Q
Spatial cellular authors heterogeneity contributes to differential drug responses in a tumor lesion and potential therapeutic resistance. Recent emerging spatial technologies such as CosMx, MERSCOPE and Xenium delineate the spatial…
September 15, 2023 / Oncol Res

  • Xie F, Xi N, Han Z, Luo W, Shen J, Luo J, Tang X, Pang T, Lv Y, Liang J, Liao L, Zhang H, Jiang Y, Li Y, He J
Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information. It is characterized by the ability…
September 12, 2023 / Nat Commun

  • Tang Z, Li Z, Hou T, Zhang T, Yang B, Su J, Song Q
Recent advances in high-throughput molecular imaging have pushed spatial transcriptomics technologies to subcellular resolution, which surpasses the limitations of both single-cell RNA-seq and array-based spatial profiling. The multichannel immunohistochemistry images…
September 4, 2023 / Int J Biol Sci

  • Du J, An ZJ, Huang ZF, Yang YC, Zhang MH, Fu XH, Shi WY, Hou J
Since its first application in 2016, spatial transcriptomics has become a rapidly evolving technology in recent years. Spatial transcriptomics enables transcriptomic data to be acquired from intact tissue sections and…
September 2, 2023 / Bioinformatics

  • Peters Couto BZ, Robertson N, Patrick E, Ghazanfar S
Motivation: Imaging-based spatial transcriptomics (ST) technologies have achieved subcellular resolution, enabling detection of individual molecules in their native tissue context. Data associated with these technologies promise unprecedented opportunity toward understanding…
August 12, 2023 / Immunol Cell Biol

  • Kulasinghe A, Wood F, Belz G
Spatial biology is a rapidly developing field which enables the visualization of protein and transcriptomic data while preserving tissue context and architecture. Initially used in discovery, there is growing promise…
August 10, 2023 / Cells

  • Chen TY, You L, Hardillo JAU, Chien MP
Spatial transcriptomic technologies enable measurement of expression levels of genes systematically throughout tissue space, deepening our understanding of cellular organizations and interactions within tissues as well as illuminating biological insights…
August 4, 2023 / Trends Biotechnol

  • Pierantoni L, Reis RL, Silva-Correia J, Oliveira JM, Heavey S
The fields of tissue bioengineering, -omics, and spatial biology are advancing rapidly, each offering the opportunity for a paradigm shift in breast cancer research. However, to date, collaboration between these…
August 4, 2023 / Science

  • Bill R, Wirapati P, Messemaker M, Roh W, Zitti B, Duval F, Kiss M, Park JC, Saal TM, Hoelzl J, Tarussio D, Benedetti F, Tissot S, Kandalaft L, Varrone M, Ciriello G, McKee TA, Monnier Y, Mermod M, Blaum EM, Gushterova I, Gonye ALK, Hacohen N, Getz G, Mempel TR, Klein AM, Weissleder R, Faquin WC, Sadow PM, Lin D, Pai SI, Sade-Feldman M, Pittet MJ
Tumor microenvironments (TMEs) influence cancer progression but are complex and often differ between patients. Considering that microenvironment variations may reveal rules governing intratumoral cellular programs and disease outcome, we focused…
August 4, 2023 / Science

  • Bressan D, Battistoni G, Hannon GJ
Spatial omics has been widely heralded as the new frontier in life sciences. This term encompasses a wide range of techniques that promise to transform many areas of biology and…