OLD Category: immunology

May 29, 2023 / Nat Med

  • Chu Y, Dai E, Li Y, Han G, Pei G, Ingram DR, Thakkar K, Qin JJ, Dang M, Le X, Hu C, Deng Q, Sinjab A, Gupta P, Wang R, Hao D, Peng F, Yan X, Liu Y, Song S, Zhang S, Heymach JV, Reuben A, Elamin YY, Pizzi MP, Lu Y, Lazcano R, Hu J, Li M, Curran M, Futreal A, Maitra A, Jazaeri AA, Ajani JA, Swanton C, Cheng XD, Abbas HA, Gillison M, Bhat K, Lazar AJ, Green M, Litchfield K, Kadara H, Yee C, Wang L
Tumor-infiltrating T cells offer a promising avenue for cancer treatment, yet their states remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 transcriptomes…
May 18, 2023 / Aging (Albany NY)

  • Jannone G, Bonaccorsi Riani E, de Magnée C, Tambucci R, Evraerts J, Ravau J, Baldin P, Bouzin C, Loriot A, Gatto L, Decottignies A, Najimi M, Sokal EM
Background: Premature senescence occurs in adult hepatobiliary diseases and worsens the prognosis through deleterious liver remodeling and hepatic dysfunction. Senescence might also arises in biliary atresia (BA), the first cause…
April 20, 2023 / Res Pract Thromb Haemost

  • Tilburg J, Andrew Stone, James Billingsley, David Scoville, Anna Pavenko, Yan Liang, Joseph Italiano, Kellie Machlus
Background: While megakaryocytes are known for making platelets, recent single cell RNA sequencing data have revealed subpopulations of megakaryocytes with predicted immunoregulatory and bone marrow niche-supporting roles. Although these studies…
April 11, 2023 / J Microbiol Immunol Infect

  • Yu SC, Chen KC, Ruby Huang RYJ
Background: Reactive lymphadenopathies such as toxoplasmosis and cytomegalovirus lymphadenitis are associated with monocytoid cell proliferation. Monocytoid cells are B-lymphocytes with an undetermined subset. Methods: Using digital spatial profiling whole transcriptome…
April 10, 2023 / mBio

  • Ng WH, Ling ZL, Kueh AJ, Herold MJ, West NP, King NJC, Mahalingam S, Liu X
Arthritogenic alphaviruses such as Ross River virus (RRV) and Chikungunya virus (CHIKV) are responsible for large-scale epidemics that cause debilitating acute and chronic musculoskeletal diseases. MXRA8 was recently discovered as…
April 8, 2023 / Am J Transplant

  • Lee CAA, Diana Wang, Martin Kauke-Navarro, Eleanor Russell-Goldman, Shuyun Xu, Kyla N. Mucciarone, Sadaf Sohrabi, Christine G. Lian, Bohdan Pomahac, George F. Murphy
Vascularized composite allografts (VCAs) of faces and extremities are subject to chronic rejection that is incompletely understood. Here we report on immunoproteomic evaluation of a full facial VCA removed 88…
April 5, 2023 / Eur Heart J Cardiovasc Pharmacother

  • Sykes RA, Neves KB, Alves-Lopes R, Caputo I, Fallon K, Jamieson NB, Kamdar A, Legrini A, Leslie H, McIntosh A, McConnachie A, Morrow A, McFarlane RW, Mangion K, McAbney J, Montezano AC, Touyz RM, Wood C, Berry C
Background: In post-coronavirus disease-19 (post-COVID-19) conditions (long COVID), systemic vascular dysfunction is implicated, but the mechanisms are uncertain, and the treatment is imprecise. Methods and results: Patients convalescing after hospitalization…
March 10, 2023 / Toxins

  • de Oliveira AK, Pramoonjago P, Rucavado A, Moskaluk C, Silva DT, Escalante T, Gutiérrez JM, Fox JW
Pathological and inflammatory events in muscle after the injection of snake venoms vary in different regions of the affected tissue and at different time intervals. In order to study such…
March 9, 2023 / J Clin Pathol

  • Ashwin H, Milross L, Wilson J, Majo J, Hang Lee JT, Calder G, Hunter B, James S, Lagos D, Signoret N, Filby A, Bayraktar OA, Fisher AJ, Kaye PM
Diffuse alveolar damage (DAD) is the histological expression of acute respiratory distress syndrome and characterises lung pathology due to infection with SARS-CoV-2, and other respiratory pathogens of clinical significance. DAD…
January 26, 2023 / J Invest Dermatol

  • LaFleur B, Curiel-Lewandrowski C, Tapia E, Parker J, White L, Sherry Chow HH, South AP
Understanding early tumorigenic events have obvious diagnostic and prognostic implications, particularly in the skin since this is the site of more US cancer diagnoses than any other organ (Rogers et…
January 24, 2023 / JCI Insight

  • Cross AR, de Andrea CE, Villalba-Esparza M, Landecho MF, Cerundolo L, Weeratunga P, Etherington RE, Denney L, Ogg G, Ho LP, Roberts IS, Hester J, Klenerman P, Melero I, Sansom SN, Issa F
Severe lung damage resulting from COVID-19 involves complex interactions between diverse populations of immune and stromal cells. In this study, we used a spatial transcriptomics approach to delineate the cells,…
January 1, 2023 / Kidney360

  • Oszwald A, Mejia-Pedroza RA, Schachner H, Aigner C, Rees A, Kain R
Pauci-immune focal necrotizing glomerulonephritis (piFNGN) involves asynchronous onset and progression of injurious lesions in biopsies. Pathologists can describe this heterogeneity within a biopsy, but translating the information into prognostic or…