
Category: neurobiology
June 8, 2023 / J Vet Intern Med
Cerebellar axonopathy in Shivers horses identified by spatial transcriptomic and proteomic analyses
Background: Shivers in horses is characterized by abnormal hindlimb movement when walking backward and is proposed to be caused by a Purkinje cell (PC) axonopathy based on histopathology. Objectives: Define…
March 14, 2023 / Cell Rep
Single-cell heterogeneity of EGFR and CDK4 co-amplification is linked to immune infiltration in glioblastoma
Glioblastoma (GBM) is the most aggressive brain tumor, with a median survival of ∼15 months. Targeted approaches have not been successful in this tumor type due to the large extent of…
March 7, 2023 / J Alzheimers Dis
Accumulation of pTau231 at the Postsynaptic Density in Early Alzheimer’s Disease
Background:: Phosphorylated cytoplasmic tau inclusions correlate with and precede cognitive deficits in Alzheimer’s disease (AD). However, pathological tau accumulation and relationships to synaptic changes remain unclear. Objective:: To address this,…
March 1, 2023 / Oncoimmunology
Macrophage infiltration promotes regrowth in MYCN-amplified neuroblastoma after chemotherapy
Despite aggressive treatment, the 5-year event-free survival rate for children with high-risk neuroblastoma is
February 16, 2023 / J Anat
The HOPX and BLBP landscape and gliogenic regions in developing human brain
Outer radial glial cells (oRGs) give rise to neurons and glial cells and contribute to cell migration and expansion in developing neocortex. HOPX has been described as a marker of…
December 20, 2022 / Nat Cancer
A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets
December 16, 2022 / Alzheimers Dement
INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer’s disease
December 13, 2022 / Neurobiol Aging
Signatures for Viral Infection and Inflammation in the Proximal Olfactory System in Familial Alzheimer’s Disease
November 22, 2022 / Cell Rep
Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology
November 21, 2022 / Acta Neuropathol Commun
Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis
November 16, 2022 / Mol Psychiatry