
OLD Category: GeoMx DSP
January 4, 2023 / Front Immunol
Spatial genomics reveals a high number and specific location of B cells in the pancreatic ductal adenocarcinoma microenvironment of long-term survivors
Background and aim: Only 10% of pancreatic ductal adenocarcinoma (PDAC) patients survive longer than five years. Factors underlining long-term survivorship in PDAC are not well understood. Therefore, we aimed to…
January 1, 2023 / Kidney360
Digital Spatial Profiling of Glomerular Gene Expression in Pauci-Immune Focal Necrotizing Glomerulonephritis
Pauci-immune focal necrotizing glomerulonephritis (piFNGN) involves asynchronous onset and progression of injurious lesions in biopsies. Pathologists can describe this heterogeneity within a biopsy, but translating the information into prognostic or…
December 27, 2022 / Sci Rep
Similar programmed death ligand 1 (PD-L1) expression profile in patients with mild COPD and lung cancer
December 23, 2022 / Front Immunol
Cuproptosis related genes associated with Jab1 shapes tumor microenvironment and pharmacological profile in nasopharyngeal carcinoma
Background: Nasopharyngeal carcinoma (NPC) is the most common subcategory of head and neck squamous cell carcinoma (HNSCC). This study focused on the roles of cuproptosis related genes and Jab1 in…
December 22, 2022 / Front Cell Dev Biol
High-throughput in situ perturbation of metabolite levels in the tumor micro-environment reveals favorable metabolic condition for increased fitness of infiltrated T-cells
Tumor-infiltrating immune cells experience significant metabolic reprogramming in the tumor microenvironment (TME), and they share similar metabolic pathways and nutrient needs with malignant cells. This positions these cell types in…
December 20, 2022 / Nat Rev Cardiol
Single-cell transcriptomics for the assessment of cardiac disease
December 20, 2022 / Nat Aging
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health
December 20, 2022 / Nat Cancer
A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets
December 19, 2022 / Transplantation
The Utility of Spatial Transcriptomics for Solid Organ Transplantation
December 16, 2022 / Alzheimers Dement
INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer’s disease
December 16, 2022 / Front Med (Lausanne)
Progress in kidney transplantation: The role for systems immunology
The development of systems biology represents an immense breakthrough in our ability to perform translational research and deliver personalized and precision medicine. A multidisciplinary approach in combination with use of…
December 13, 2022 / Neurobiol Aging