CosMx™ SMI Datasets

See More Spatial Biology from Precious Samples 

CosMx™ Spatial Molecular Imager (shipping now) is the first fully-integrated multiomics single-cell spatial biology solution and enables researchers to investigate morphologically-intact tissues at unprecedented plex, resolution and cell numbers. CosMx SMI enables imaging of more than 1,000 RNA and over 64 protein analytes at subcellular resolutions across more than 1 million cells within both fresh frozen and formalin-fixed paraffin-embedded (FFPE) tissue samples.

Analyzing RNA and protein in FFPE samples is known to be challenging due to their limited quantities, sample degradation and workflows required to work with them. The CosMx SMI system leverages simple sample preparation workflows and robust in situ hybridization chemistry and works with any sample type. 

​We have generated open-source datasets for FFPE samples to highlight the power of  CosMx SMI. CosMx SMI combines ultimate sensitivity, specificity, robust cell segmentation and broad, high plex panels to enable researchers to explore the cell atlas, cell-cell interactions and phenotypes of the tissue microenvironment.​ 

Available Datasets

Human Liver (RNA)

Explore spatially resolved single-cell data from two FFPE samples of normal and cancerous liver tissue to reveal spatial insights into the Disease State, Tissue Microenvironment, Protein imaging based cell segmentation, a subcellular expression map of 1000+ genes, and a spatially-resolved cell type map. 

Human Non-Small Cell Lung Cancer (RNA)

Explore datasets from eight NSCLC FFPE tissues and uncover spatial insights into Cell Typing and Mapping, Ligand-Receptor Interaction and Differential Expression. 

Note: Non-Small Cell Lung Cancer data was collected on a prototype of CosMx™ Spatial Molecular Imager. See Liver FFPE Dataset for data collected on the commercially available CosMx SMI.