Neuroscience is a complex field that involves studying highly specialized cells and tissue structures that work together in concert. Researchers study the morphology, structure, and spatial organization of neurons to better understand neuronal development. They look for relevant biomarkers for the onset and progression of neurodegeneration and neuroinflammation as well as novel targets for therapeutics. Cell atlases of the brain are mapped to explain how different cell types such as neurons, microglia, and oligodendrocytes interact with each other as well as peripheral immune cells.
We are just beginning to unravel the secrets behind the function of the Central Nervous System (CNS). Many different cell types interact with each other in a choreographed manner. Preclinical models and developmental biology give us some insight into the biology of the CNS, but it can be challenging to find suitable animal models. The immune response to infectious disease, neuroinflammation, and neurodegeneration in the CNS doesn’t fit the same paradigm as the systemic immune response due to the blood brain barrier. Add to this the fact that brain samples are scarce and neuroscience research becomes particularly difficult to navigate.
Your Trusted Partner for Neuroscience Research
NanoString’s integrated, multiomic research solutions allow you to study neurodegeneration, neuroinflammation, and neuronal development from the level of single cells to multicellular tissue compartments and patient cohorts. Wherever you are headed with your neuroscience research, we can get you actionable insights from FFPE, fresh frozen tissue, cell lysates, and biofluids. Profile the expression of 800+ genes from a single sample with the nCounter® Analysis System. Spatially profile the whole transcriptome and select protein targets within distinct tissue compartments and cell populations with the GeoMx® Digital Spatial Profiler (DSP). Obtain the highest plex single cell and subcellular spatial multiomics data with the CosMx™ Spatial Molecular Imager (SMI).
NanoString has been developing innovative research tools for over 20 years and we believe in partnering with you to enable your research.
The CosMx™ SMI and decoder probes are not offered and/or delivered to the Federal Republic of Germany for use in the Federal Republic of Germany for the detection of cellular RNA, messenger RNA, microRNA, ribosomal RNA and any combinations thereof in a method used in fluorescence in situ hybridization for detecting a plurality of analytes in a sample without the consent of the President and Fellows of Harvard College (Harvard Corporation) as owner of the German part of EP 2 794 928 B1. The use for the detection of cellular RNA, messenger RNA, microRNA, ribosomal RNA and any combinations thereof is prohibited without the consent of the President and Fellows of Harvard College (Harvard Corporation).
The CosMx™ SMI and decoder probes are not offered and/or delivered to the following UPC member states* for use in these countries for the detection of RNA in a method used for the detection of a plurality of analytes in a cell or tissue sample without the consent of the President and Fellows of Harvard College (Harvard Corporation) as owner of the Unitary Patent EP 4 108 782 B1. The use for the detection of RNA is prohibited without the consent of the President and Fellows of Harvard College (Harvard Corporation).
* Austria, Belgium, Bulgaria, Denmark, Estonia, Finland, France, Germany, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Portugal, Slovenia, Sweden
One Suite of Tools. Unlimited Potential.
- Discover predictive and prognostic biomarkers
- Develop signatures associated with neurodegenerative and neuroinflammatory disorders
- Evaluate mechanisms of treatment response
- Monitor disease biomarkers in clinical trials
- Screen cells for drug development
Digital Spatial Profiler
- Discover and develop spatial gene signatures
- Characterize the heterogeneity of brain tissue in health and disease
- Study the effect of plaques and neurofibrillary tangles on astrocytes and microglia
- Characterize the localized treatment response
- Study the localized response to infectious disease in the brain
Spatial Molecular Imager
- Discover unique functions of different cell types in the brain and peripheral nervous system
- Discover unique cell-cell interactions
- Define cellular neighborhoods
- Reveal functional, cellular, and temporal changes spatially at single-cell and subcellular resolution
- Characterize axonal growth, neuronal migration, and synapse formation
A Holistic View of Neuroscience Across Multiple Dimensions
NanoString’s collection of assays across all three of our platforms delivers a family of multiplex gene and protein expression assays for bulk and spatial analysis in human and mouse samples that support basic and translational studies on CNS development, health, and disease. Curated content for Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis (ALS), Stroke, Traumatic Brain Injury, and Multiple Sclerosis (MS) enables you to gain a holistic understanding of the function and molecular biology of neuronal cell types across the brain and peripheral nervous system.
Select nCounter Neuroscience Gene Expression Panels
The nCounter Neuroscience portfolio includes several curated, off-the-shelf panels that cover the pathways and markers involved in neurodegeneration, neuroinflammation, and the biology of glial cells. Create a panel from scratch for targets from any species by working with our bioinformatics team to develop probes for a Custom CodeSet or spike in up to 55 targets of your choice to any off-the-shelf panel.
Profile expression of 770 genes involved in the six fundamental themes of neurodegeneration: neurotransmission, neuron-glia interaction, neuroplasticity, cell structure integrity, neuroinflammation, and metabolism.
Study the interaction of the immune system with the CNS that underlies neuronal disorders and injury, assessment of neurotransmission, neuron-glia interactions, neuroplasticity, cell integrity, neuroinflammation, and metabolism.
Profile 770 genes across 50 pathways involved in glial cell biology, including the cell stress and damage response, inflammation and peripheral immune cell invasion, glial cell activation, and neurotransmission.
GeoMx DSP Assays for Neuroscience
Spatially profile expression of the human or mouse transcriptome in select tissue structures or cell populations in FFPE or fresh frozen tissue sections or profile select protein targets involved in neurodegenerative and neuroinflammatory disorders. Take advantage of the Spatial Proteogenomics workflow to discover novel multiomic biomarkers by spatially profiling RNA and protein simultaneously from the same tissue section.
Spatially profile upwards of 18,000 protein coding genes in distinct tissue compartments and cell populations.
Profile the in situ expression of the whole mouse transcriptome in FFPE and fresh frozen tissue.
CosMx SMI Assays for Neuroscience Research
CosMx assays for neuroscience research include a 1000 plex RNA panel for human or mouse that includes markers for robust cell and tissue typing, ligand-receptor interactions, metabolism, circadian rhythm, antigen presentation, cell damage, stress response, and wound healing. For studying mouse models of neurological disease you can profile 1000 highly curated RNA targets with the Mouse Neuroscience Panel or 68 proteins with the Mouse Neuroscience Protein Panel.
Profile expression of 1000 highly curated targets at subcellular resolution and customize by adding up to 50 targets. Identify up to 100 unique ligandreceptor pairs.
Profile the expression of 1000 RNA targets that enable the identification of 42 distinct cell types in the mouse brain and cover targets involved in the biology of neuroinflammatory and neurodegenerative diseases such as AML, Huntington’s, Parkinson’s, and Alzheimer’s. Customize with up to 50 targets.
Profile the expression of 64 protein targets in mouse models of Alzheimer’s disease and other neurodegenerative disorders. Coverage includes markers for disease pathology, immune response, and neural, glial, and immune cell typing. Customize with up to 8 additional protein targets.
Spotlight on Success
“The GeoMx DSP is a workhorse in the lab for hypothesis testing… Complementing the single-neuron resolution of GeoMx, we rely on the CosMx SMI to achieve true subcellular spatial analyses and uncover cell-cell interactions… NanoString’s consistent advancements in panel development and plexity provide us with the confidence that they will continue empowering neuroscientists to explore complex questions.”
Miranda Orr, PhD
Assistant Professor, Gerontology and Geriatric Medicine, Wake Forest School of Medicine
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Cerebellar axonopathy in Shivers horses identified by spatial transcriptomic and proteomic analyses
Background: Shivers in horses is characterized by abnormal hindlimb movement when walking backward and is proposed to be caused by a Purkinje cell (PC) axonopathy based on histopathology. Objectives: Define region-specific differences in gene expression within the lateral cerebellar hemisphere and compare cerebellar protein expression between Shivers horses and controls.
Single-cell heterogeneity of EGFR and CDK4 co-amplification is linked to immune infiltration in glioblastoma
Glioblastoma (GBM) is the most aggressive brain tumor, with a median survival of ∼15 months. Targeted approaches have not been successful in this tumor type due to the large extent of intratumor heterogeneity.
Accumulation of pTau231 at the Postsynaptic Density in Early Alzheimer’s Disease
Background:: Phosphorylated cytoplasmic tau inclusions correlate with and precede cognitive deficits in Alzheimer’s disease (AD). However, pathological tau accumulation and relationships to synaptic changes remain unclear.