GeoMx® Digital Spatial Profiler

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GeoMx® Digital Spatial Profiler - Spatial Biology

GeoMx DSP: Your Guide to Spatial Biology

The GeoMx Digital Spatial Profiler (DSP) provides morphological context in spatial transcriptomics and spatial proteomics experiments from just one slide.

From discovery to translational research, the GeoMx DSP is the most flexible and robust spatial biology solution designed to conform to your ever-changing research needs.

Imagine the Possibilities with GeoMx DSP

Heterogeneity resolved

Heterogeneity. Resolved.

Spatially resolve tissues and cell populations with functional segmentation.

Detect more without compromise

Detect more.
Without compromise.

Detect more of the transcriptome and proteome with the highest plex and highest sensitivity.

Consistent results and reliable answers

Consistent results. Reliable answers.

Multi-sample analysis and cohort studies made easy with unmatched reproducibility and scalability.

Unlock your samples with confidence

Unlock your samples. With confidence.

Get proven, robust results from FFPE, FF tissues and TMAs using standard histology workflows.

Structure dictates function. Think outside the box

Structure dictates function. Think outside the box.

Profile functionally distinct cells and structures to get a complete picture of the biology that matters.

Analyze today and publish faster

Analyze today.
Publish faster.

Don’t wait. Get publication-ready results faster with higher throughput and an integrated data analysis software.

How it Works

The GeoMx DSP workflow seamlessly integrates with current histology or genomics workflows to help researchers obtain robust and reproducible spatial multiomics data quickly.

Whole tissue sections, FFPE or fresh frozen, can be imaged and stained for RNA or protein. Researchers can then precisely select which tissue compartments or cell types to profile based on the biology, and subsequently count expression levels using either the nCounter Analysis System or an Illumina Sequencer.

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Biology-driven Profiling – Spatial Genomics

Capture tissue heterogeneity through flexible profiling

Geometric profiling

Geometric Profiling

Segmentation

Segmentation

Cell type specific

Cell Type Specific

Contour

Contour

Gridded

Gridded

What is the heterogeneity of expression in different regions of my tissue?

What is the expression profile of distinct biological compartments (e.g., Tumor-TME)?

What is the expression profile of a specific cell population in my tissue?

How does the immune environment change on either side of an infiltrate boundary?

What novel targets are uncovered with deep mapping of a specific tissue region?

GeoMx Publications

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Multiplexed Digital Spatial Protein Profiling Reveals Distinct Phenotypes of Mononuclear Phagocytes in Livers with Advanced Fibrosis.

Background and Aims: Intrahepatic mononuclear phagocytes (MPs) are critical for the initiation and progression of liver fibrosis. In this study, using multiplexed digital spatial protein profiling, we aimed to derive a unique protein signature predicting advanced liver fibrosis.

A Novel Transcriptome Approach to the Investigation of the Molecular Pathology of Vitreous and Retinal Detachment.

Retinal detachment (RD) is one of the most common, sight-threatening ocular conditions requiring emergency intervention. Posterior vitreous detachment (PVD) occurs in the majority of an aging population whereby the vitreous body separates from the retina.

The prognostic value and molecular properties of tertiary lymphoid structures in oesophageal squamous cell carcinoma.

Background: Tertiary lymphoid structures (TLSs) play key roles in tumour adaptive immunity. However, the prognostic value and molecular properties of TLSs in oesophageal squamous cell carcinoma (ESCC) patients have not been studied.

Related Resources

See All Resources
Brochure/eBook GeoMx DSP – Brochure
Product Bulletin GeoMx Human Whole Transcriptome Atlas – Product Bulletin
Whitepaper GeoMx COVID-19 Applications – Whitepaper
Product Bulletin GeoMx Cancer Transcriptome Atlas (CTA) – Product Bulletin
Blog Post Spatial Transcriptomics: Birth of GeoMx® Digital Spatial Profiler

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