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GeoMx® Digital Spatial Profiler

Discover Where Biology Happens

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GeoMx DSP: Your Guide to Spatial Biology

The GeoMx Digital Spatial Profiler (DSP) provides morphological context in spatial transcriptomics and spatial proteomics experiments from just one slide.

From discovery to translational research, the GeoMx DSP is the most flexible and robust spatial biology solution designed to conform to your ever-changing research needs.

Imagine the Possibilities with GeoMx DSP

Heterogeneity. Resolved.

Spatially resolve tissues and cell populations with functional segmentation.

Detect more. Without compromise.

Detect more of the transcriptome and proteome with the highest plex and highest sensitivity.

Consistent results. Reliable answers.

Multi-sample analysis and cohort studies made easy with unmatched reproducibility and scalability.

Unlock your samples. With confidence.

Get proven, robust results from FFPE, FF tissues and TMAs using standard histology workflows.

Structure dictates function. Think outside the box.

Profile functionally distinct cells and structures to get a complete picture of the biology that matters.

Analyze today. Publish faster.

Don’t wait. Get publication-ready results faster with higher throughput and an integrated data analysis software.

How it Works

The GeoMx DSP workflow seamlessly integrates with current histology or genomics workflows to help researchers obtain robust and reproducible spatial multiomics data quickly.

Whole tissue sections, FFPE or fresh frozen, can be imaged and stained for RNA or protein. Researchers can then precisely select which tissue compartments or cell types to profile based on the biology, and subsequently count expression levels using either the nCounter Analysis System or an Illumina Sequencer.

Biology-driven Profiling

Capture tissue heterogeneity through flexible profiling

Geometric Profiling

Segmentation

Cell Type Specific

Contour

Gridded

What is the heterogeneity of expression in different regions of my tissue?

What is the expression profile of distinct biological compartments (e.g., Tumor-TME)?

What is the expression profile of a specific cell population in my tissue?

How does the immune environment change on either side of an infiltrate boundary?

What novel targets are uncovered with deep mapping of a specific tissue region?

GeoMx Publications

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Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer.

Neuronal nerve processes in the tumor microenvironment were highlighted recently. However, the origin of intra-tumoral nerves remains poorly known, in part because of technical difficulties in tracing nerve fibers via conventional histological preparations.

Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer.

Purpose: Cancer-associated fibroblasts (CAF) have been implicated as potential mediators of checkpoint immunotherapy response. However, the extensive heterogeneity of these cells has precluded rigorous understanding of their immunoregulatory role in the tumor microenvironment.

Spatial profiling reveals association between WNT pathway activation and T-cell exclusion in acquired resistance of synovial sarcoma to NY-ESO-1 transgenic T-cell therapy.

Background: Genetically engineered T-cell immunotherapies for adoptive cell transfer (ACT) have emerged as a promising form of cancer treatment, but many of these patients develop recurrent disease. Furthermore, delineating mechanisms of resistance may be challenging since the analysis of bulk tumor profiling can be complicated by spatial heterogeneity.

in Your Lab

Related Resources

See All Resources
Brochure/eBook GeoMx DSP – Brochure
Product Bulletin GeoMx Human Whole Transcriptome Atlas – Product Bulletin
Whitepaper GeoMx COVID-19 Applications – Whitepaper
Product Bulletin GeoMx Cancer Transcriptome Atlas (CTA) – Product Bulletin
Blog Spatial Transcriptomics: Birth of GeoMx® Digital Spatial Profiler