CosMx™ RNA Assays

High-Plex Single-Cell Spatial

CosMx™ SMI RNA Assays enable high-plex analysis of up to 6000 genes from a single FFPE slide with spatial context at cellular and sub-cellular levels. CosMx RNA assays are designed to provide robust cell typing, cell-cell interaction analysis, and more in a wide range of human and mouse tissues and disease states. Profile expression of highly curated targets at subcellular resolution and customize some assays with your own targets.

Choose the RNA Assay that best suits your research needs:

How it works

The CosMx RNA Assays are fully validated for the CosMx Spatial Molecular Imager, providing robust tissue mapping, cell typing, and analysis of cell states and interactions on a wide range of human and mouse tissues. CosMx RNA assays are designed to provide a wealth of genomic breadth with ultra-high-plex RNA panels that can provide high numbers of genes detected per sample.



High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging

Resolving the spatial distribution of RNA and protein in tissues at subcellular resolution is a challenge in the field of spatial biology. We describe spatial molecular imaging, a system that measures RNAs and proteins in intact biological samples at subcellular resolution by performing multiple cycles of nucleic acid hybridization of fluorescent molecular barcodes.

Related Resources

Whitepaper Evaluating the Technical Performance of Single-Cell Spatial Molecular Imaging Technologies
Product Bulletin CosMx™ Human 6K Discovery Panel Bulletin
Gene/Probe List CosMx Human 6K Discovery Panel Gene List
Blog Post Complex Cell Segmentation and Its Significance in Spatial Biology
Manual/Instructions NanoU Training Videos