OLD Category: Oncology

Immune suppression in the tumor-draining lymph node corresponds with distant disease recurrence in patients with melanoma

• van Krimpe An, Vivian I.V. Gerretsen, Evalyn E.A.P. Mulder, Mandy van Gulijk, Thierry P.P. van den Bosch, Jan von der Thüsen, Dirk J. Grünhagen, Cornelis Verhoef, Dana Mustafa, Joachim G. Aerts, Ralph Stadhouders, Floris Dammeijer

Multidimensional Immunophenotyping of Intraductal Papillary Mucinous Neoplasms Reveals Novel T Cell and Macrophage Signature

• Eckhoff AM, Fletcher AA, Landa K, Iyer M, Nussbaum DP, Shi C, Nair SK, Allen PJ

Spatial meta-transcriptomics reveal associations of intratumor bacteria burden with lung cancer cells showing a distinct oncogenic signature

• Wong-Rolle A, Dong Q, Zhu Y...Jin C, Germain RN, Zhao C

Single-cell profiling of microenvironment components by spatial localization in pancreatic ductal adenocarcinoma

• Han S, Fu D, Tushoski GW, Meng L, Herremans KM, Riner AN, Geoge TJ, Huo Z, Hughes SJ

The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution

• Nirmal AJ, Maliga Z, Vallius T...Murphy GF, Santagata S, Sorger PK

Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort

• Italiano A, Bessede A, Pulido M, Bompas E, Piperno-Neumann S, Chevreau C, Penel N, Bertucci F, Toulmonde M, Bellera C, Guegan JP, Rey C, Sautès-Fridman C, Bougoüin A, Cantarel C, Kind M, Spalato M, Dadone-Montaudie B, Le Loarer F, Blay JY, Fridman WH

Spatial and Transcriptomic Analysis of Perineural Invasion in Oral Cancer

• Schmitd LB, Perez-Pacheco C, Bellile EL, Wu W, Casper K, Mierzwa M, Rozek LS, Wolf GT, Taylor JMG, D'Silva NJ

Dissecting Tissue Compartment-Specific Protein Signatures in Primary and Metastatic Oropharyngeal Squamous Cell Carcinomas

• Sadeghirad H, Monkman J, Mehdi AM, Ladwa R, O’Byrne K, Hughes BGM, Kulasinghe A

Spatial transcriptome of a germinal center plasmablastic burst hints at MYD88/CD79B mutants-enriched diffuse large B-cell lymphomas

• L'Imperio V, Morello G, Vegliante MC, Cancila V, Bertolazzi G, Mazzara S, Belmonte B, Mangogna A, Balzarini P, Corral L, Lopez G, Di Napoli A, Facchetti F, Pagni F, Tripodo C

CXCL14 promotes a robust brain tumor-associated immune response in glioma

• Kumar A, Mohamed E, Tong S, Chen K, Mukherjee J, Lim Y, Wong CM, Boosalis Z, Shai A, Pieper RO, Gupta N, Perry A, Bollen AW, Molinaro AM, Solomon DA, Shieh JTC, Phillips JJ

Discovery of biomarkers of resistance to immune checkpoint blockade in non-small-cell lung cancer (NSCLC) using high-plex digital spatial profiling

• Moutafi M, Martinez-Morilla S, Divakar P...Herbst R, Schalper KA, Rimm DL

ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer

• Ozturk H, Cingoz H, Tufan T, Yang J, Adair SJ, Tummala KS, Kuscu C, Kinali M, Comertpay G, Nagdas S, Goudreau BJ, Luleyap HU, Bingul Y, Ware TB, Hwang WL, Hsu KL, Kashatus DF, Ting DT, Chandel NS, Bardeesy N, Bauer TW, Adli M