OLD Category: regulatory biology

Complement factor H–deficient mice develop spontaneous hepatic tumors

• Laskowski J, Renner B, Pickering MC, Serkova NJ, Smith-Jones PM, Clambey ET, Nemenoff RA, Thurman JM

Heritable gene expression variability and stochasticity govern clonal heterogeneity in circadian period

• Nikhil KL, Korge S, Kramer A

Adoptive Cell Transfer of Regulatory T Cells Exacerbates Hepatic Steatosis in High-Fat High-Fructose Diet-Fed Mice

• Van Herck MA, Vonghia L, Kwanten WJ, Vanwolleghem T, Ebo DG, Michielsen PP, De Man JG, Gama L, De Winter BY, Francque SM

A phase Ib open-label dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of cobimetinib (GDC-0973) and ipatasertib (GDC-0068) in patients with locally advanced or metastatic solid tumors

• Shapiro GI, LoRusso P, Cho DC...Sanabria-Bohorquez S, Meng RD, Bendell JC

Epigenetic Silencing of LMX1A Contributes to Cancer Progression in Lung Cancer Cells

• Wu TH, Chang SY, Shih YL, Chian CF, Chang H, Lin YW

Epigenetic regulator function through mouse gastrulation

• Grosswendt S, Kretzmer H, Smith ZD, Kumar AS, Hetzel S, Wittler L, Klages S, Timmermann B, Mukherji S, Meissner A

Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity

• Borodovsky A, Barbon CM, Wang Y...Fawell S, Schuller AG, Mele DA

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

• Lepelley A, Martin-Niclós MJ, Le Bihan M...Manel N, Crow YJ, Frémond ML

PTEN Function at the Interface between Cancer and Tumor Microenvironment: Implications for Response to Immunotherapy

• Conciatori F, Bazzichetto C, Falcone I, Ciuffreda L, Ferretti G, Vari S, Ferraresi V, Cognetti F, Milella M

MAM domain containing 2 is a potential breast cancer biomarker that exhibits tumour‐suppressive activity

• Lee H, Park B, Soon Kang J, Cheon Y, Lee S, Jae Maeng P

Novel Approaches for Assessing Circadian Rhythmicity in Humans: A Review

• Dijk DJ, Duffy JF

An HNSCC syngeneic mouse model for tumor immunology research and preclinical evaluation

• Fu Y, Tian G, Li J, Zhang Z, Xu K