CosMx™ Human 6K Discovery Panel
The CosMx™️ 6K Discovery panel enables the spatial analysis of the entire reactome at a single cell level, providing a comprehensive means to examine and understand the spatial distribution of cellular pathways.
Applications
Semi-supervised cell typing using Allen Human M1 Atlas
nb_clus #1 (motorClus20_custom_qc_2)
Novel clusters: Astro_2, L2.Neuron_1, Oligo_2, Oligo_3, e, pia.mater
Discovery of spatially co-expressed ligands in diverse types of cells in FFPE liver cancer
Ligands Co-localization Identify Rare Cell Type in Human Brain: Sst Chodl neurons
Unsupervised clustering is performed on the correlation matrix of ligands’ neighborhood expression profiles to identify clusters of co-localized ligands. One ligand cluster consists of 3 ligands, SST, NPY, CORT, and shows strong correlation in their neighborhood expression profiles. The co-expression of those 3 ligands identify a rare cell type, Sst Chodl interneurons, in the dataset.
Shown across the two volcano plots, the CosMx 6K Discovery Panel identifies a larger number of statistically significant and biologically meaningful genes associated with Kidney cancer as compared to the CosMx Universal Cell Characterization (1K) Panel.
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Research
High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging
Resolving the spatial distribution of RNA and protein in tissues at subcellular resolution is a challenge in the field of spatial biology. We describe spatial molecular imaging, a system that measures RNAs and proteins in intact biological samples at subcellular resolution by performing multiple cycles of nucleic acid hybridization of fluorescent molecular barcodes.
