nCounter® CVD Pathophysiology Panel

Helping Your Research

Cardiovascular diseases (CVD) are the leading cause of death and disability globally. Unsurprisingly, research in this field is vast and scientists are looking for tools that can provide simple, actionable answers to help guide discoveries. With a number of CVD drugs coming off patent and an explosion of immune therapies with cardiotoxic side effects entering the market, scientists must deepen their understanding of cardiotoxic side effects and continuously innovate to stay on top of this rapidly evolving field.

The nCounter® CVD Pathophysiology Panel enables researchers to explore how cardiovascular disfunction contributes to heart disease, hypertension and arteriosclerosis. The panel provides molecular insights with quick, actionable results. Study the cardiotoxic effects of immune therapies or assess the role of aging and cell renewal in cardiac regenerative medicine.   

Wheel diagram of pathophyisiology

How It Works

Feature Details
Customization
Data Analysis
Feature Details

Features

  • Directly profile 800 genes across 50 pathways involved in CVD pathophysiology
    • Cardiovascular Pathology
    • Cardiovascular Physiology
    • Vascular Inflammation
    • Cellular Aging & Renewal
    • Metabolism
    • Mechano Signaling
    • Regulatory Signaling
    • Epigenetic Remodeling
  • Measure cardiotoxicities resulting from therapeutic treatment
  • Study the MOA of approved CVD drugs
  • Explore cardiomyocyte recovery and regeneration
  • Quantify the presence and relative abundance of 16 cell types present in cardiac tissue
  • Compatible with a variety of sample types including blood, cardiac tissue, organoids, engineered cell lines, explants, and organs on a chip
  • Generate data in 24 hours with less than 30 minutes hands on time and simple data analysis
Customization

Customization

Customize your research project by adding up to 55 user-defined genes of interest with nCounter Panel Plus. Panel Plus capacity enables researchers to address content specific to their cardiovascular research areas of interest. Expand on pathways and core themes of the panel or include infectious disease content (i.e. COVID).

Data Analysis

Data Analysis

In addition to the standard nSolver™ Analysis Software, genes included in the CVD Pathophysiology Panel are organized and linked to various advanced analysis modules to allow for efficient analysis of relevant pathways.

Analysis modules available for CVD Pathophysiology:

  • Normalization
  • Quality Control
  • Individual Pathway Analysis
  • Cell Profiling
  • Differential Expression
  • Gene Set Analysis
  • Built-in compatibility for Panel Plus and Protein analysis

ROSALIND® Platform

ROSALIND is a cloud-based platform that enables scientists to analyze and interpret differential gene expression data without the need for bioinformatics or programming skills. ROSALIND makes analysis of nCounter data easy, with guided modules for:

  • Normalization
  • Quality Control
  • Individual Pathway Analysis Differential Expression
  • Gene Set Analysis

nCounter customers can access ROSALIND free of charge at https://www.onramp.bio/nanostring.

Panel Selection Tool

Find the gene expression panel for your research with Panel Pro

Find Your Panel

Publications & Posters

View All Publications

Spatial multiomics of arterial regions from cardiac allograft vasculopathy rejected grafts reveal novel insights into the pathogenesis of chronic antibody-mediated rejection

Cardiac allograft vasculopathy (CAV) causes late graft failure and mortality after heart transplantation. Donor-specific antibodies (DSAs) lead to chronic endothelial cell injury, inflammation, and arterial intimal thickening.

Biologically derived epicardial patch induces macrophage mediated pathophysiologic repair in chronically infarcted swine hearts

There are nearly 65 million people with chronic heart failure (CHF) globally, with no treatment directed at the pathologic cause of the disease, the loss of functioning cardiomyocytes. We have an allogeneic cardiac patch comprised of cardiomyocytes and human fibroblasts on a bioresorbable matrix.

Human leukocyte antigen class I antibody-activated endothelium promotes CD206+ M2 macrophage polarization and MMP9 secretion through TLR4 signaling and P-selectin in a model of antibody-mediated rejection and allograft vasculopathy

HLA donor-specific antibodies (DSA) elicit alloimmune responses against the graft vasculature, leading to endothelial cell (EC) activation and monocyte infiltration during antibody-mediated rejection (AMR). AMR promotes chronic inflammation and remodeling, leading to thickening of the arterial intima termed transplant vasculopathy or cardiac allograft vasculopathy (CAV) in heart transplants.

Product Information

Product Specifications
Themes
Cell Profiling
Catalog Information
Product Specifications

Product Specifications

Themes

Panel Themes

The CVD Pathophysiology Panel includes annotations across 8 functional themes related to cardiovascular disfunction and disease. Pathway coverage is outlined in the table below.

Cell Profiling

Cardiac Cell Profiling Feature

Genes included in the CVD Pathophysiology Panel provide unique cell profiling data to measure the relative abundance of 16 different cardiac cell types. The table below summarizes the genes included in each cell type signature, as qualified through biostatistical approaches and selected literature in the field of cardiovascular disease.

Catalog Information

Catalog Information

Related Resources

Product Bulletin nCounter CVD Pathophysiology Panel – Product Bulletin
Manual/Instructions NanoU Training Videos

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