OLD Category: methods

February 13, 2023 / Curr Opin Organ Transplant

  • Virmani S, Rao A, Menon MC
Purpose of review: To review novel modalities for interrogating a kidney allograft biopsy to complement the current Banff schema. Recent findings: Newer approaches of Artificial Intelligence (AI), Machine Learning (ML),…
February 4, 2023 / Int J Mol Sci

  • Sheng W, Zhang C, Mohiuddin TM, Al-Rawe M, Zeppernick F, Falcone FH, Meinhold-Heerlein I, Hussain AF
Traditional immunohistochemistry (IHC) has already become an essential method of diagnosis and therapy in cancer management. However, this antibody-based technique is limited to detecting a single marker per tissue section.…
January 27, 2023 / BMC Bioinformatics

  • Pont F, Cerapio JP, Gravelle P, Ligat L, Valle C, Sarot E, Perrier M, Lopez F, Laurent C, Fournié JJ, Tosolini M
Background:: The development of single-cell technologies yields large datasets of information as diverse and multimodal as transcriptomes, immunophenotypes, and spatial position from tissue sections in the so-called ’spatial transcriptomics’. Currently…
January 16, 2023 / Comput Struct Biotechnol J

  • Yue L, Feng Liu, Jiongsong Hu, Pin Yang, Yuxiang Wang, Junguo Dong, Wenjie Shu, Xingxu Huang, Shengqi Wang
Advances in transcriptomic technologies have deepened our understanding of the cellular gene expression programs of multicellular organisms and provided a theoretical basis for disease diagnosis and therapy. However, both bulk…
December 30, 2022 / Nat Method

  • Bost P, Schulz D, Engler S, Wasserfall C, Bodenmiller B
Recent advances in multiplexed imaging methods allow simultaneous detection of dozens of proteins and hundreds of RNAs, enabling deep spatial characterization of both healthy and diseased tissues. Parameters for the…
December 21, 2022 / Brief Bioinform

  • Tang Z, Zhang T, Yang B, Su J, Song Q
December 20, 2022 / Nat Rev Cardiol

  • Miranda AMA, Janbandhu V, Maatz H, Kanemaru K, Cranley J, Teichmann SA, Hübner N, Schneider MD, Harvey RP, Noseda M
December 20, 2022 / Nat Aging

  • NIH SenNet Consortium
December 19, 2022 / Transplantation

  • Li JSY, Raghubar AM, Matigian NA, Ng MSY, Rogers NM, Mallett AJ
December 16, 2022 / Front Med (Lausanne)

  • Johnson AC, Silva JAF, Kim SC, Larsen CP
The development of systems biology represents an immense breakthrough in our ability to perform translational research and deliver personalized and precision medicine. A multidisciplinary approach in combination with use of…
December 13, 2022 / Genome Biol

  • Park J, Kim J, Lewy T, Rice CM, Elemento O, Rendeiro AF, Mason CE
December 10, 2022 / Nat Commun

  • Shen R, Liu L, Wu Z, Zhang Y, Yuan Z, Guo J, Yang F, Zhang C, Chen B, Feng W, Liu C, Guo J, Fan G, Zhang Y, Li Y, Xu X, Yao J