
Category: methods
March 3, 2023 / Genome Biol
SRTsim: spatial pattern preserving simulations for spatially resolved transcriptomics.
Spatially resolved transcriptomics (SRT)-specific computational methods are often developed, tested, validated, and evaluated in silico using simulated data. Unfortunately, existing simulated SRT data are often poorly documented, hard to reproduce,…
March 2, 2023 / Nat Rev Genet
Methods and applications for single-cell and spatial multi-omics.
The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome from single cells is transforming our understanding of cell biology in health and disease. In less than a decade,…
February 23, 2023 / Transplantation
Contribution of Proteomics in Transplantation: Identification of Injury and Rejection Markers.
Solid organ transplantation saves thousands of lives suffering from end-stage diseases. Although early transplants experienced acute organ injury, medical breakthroughs, such as tissue typing, and use of immunosuppressive agents have…
February 13, 2023 / Curr Opin Organ Transplant
Allograft tissue under the microscope: only the beginning.
Purpose of review: To review novel modalities for interrogating a kidney allograft biopsy to complement the current Banff schema. Recent findings: Newer approaches of Artificial Intelligence (AI), Machine Learning (ML),…
February 4, 2023 / Int J Mol Sci
Multiplex Immunofluorescence: A Powerful Tool in Cancer Immunotherapy.
Traditional immunohistochemistry (IHC) has already become an essential method of diagnosis and therapy in cancer management. However, this antibody-based technique is limited to detecting a single marker per tissue section.…
December 21, 2022 / Brief Bioinform
spaCI: deciphering spatial cellular communications through adaptive graph model.
December 20, 2022 / Nat Rev Cardiol
Single-cell transcriptomics for the assessment of cardiac disease.
December 20, 2022 / Nat Aging
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.
December 19, 2022 / Transplantation
The Utility of Spatial Transcriptomics for Solid Organ Transplantation.
December 13, 2022 / Genome Biol
Spatial omics technologies at multimodal and single cell/subcellular level.
December 10, 2022 / Nat Commun