NanoString Highlights Research Presented at the 2018 Annual Meeting of the Society of Immunotherapy for Cancer (SITC)
Includes Data from More than Twenty-Five Studies, Including Six Using GeoMx Digital Spatial Profiler
“We are thrilled to see a number of high-profile abstracts that include data from our GeoMx Digital Spatial Profiler at the 2018
More than 25 abstracts using NanoString’s nCounter platform will be presented at the SITC Annual Meeting, being held at the
Six studies included the use of NanoString’s GeoMx Digital Spatial Profiler (DSP) platform in immuno-oncology research. These abstracts include numbers 031, P113, P131, P389, P428 and P429 that are included in the table below. DSP allows for digital quantification of protein and gene expression from discrete regions of FFPE tissue in an automated and multiplex format. DSP is expected to be commercially available with the launch of a new instrument planned for mid-2019, and is currently accessible through the company’s Technology Access Program (TAP).
Each year,
At the 2018 SITC Annual Meeting,
| Abstract # | Title | Presenting Author |
| O31 | Tumor infiltrating lymphocyte recruitment after peri-lymphatic IRX-2 cytokine immunotherapy in resectable breast cancer and head and neck carcinoma | David Page, MD Providence Portland Cancer Center, Portland, OR, USA |
| O45 | Refractory renal cell cancer (RCC) exhibits high adenosine A2A receptor (A2AR) expression and prolonged survival following treatment with the A2AR antagonist, CPI-444 | Lawrence Fong, MD University of California, San Francisco, CA, USA |
| P25 | Consistent pharmacodynamics and immunological responses to the TLR9 agonist, SD-101, following intratumoral injection in multiple cancer types | Albert Candia, PhD Dynavax Technologies, Berkeley, CA, USA |
| P35 | Development of biomarkers to assess adenosine generation & activity in support of clinical trials conducted with the adenosine receptor antagonist AB928 | Daniel DiRenzo, PhD Arcus Biosciences, Hayward, CA, USA |
| P43 | The presence of exhausted CD8+ T cells identifies a subset of immunogenic ER+ breast cancer patient tumors | Colt Egelston, PhD Beckman Research Institute, City of Hope, Duarte, CA, USA |
| P53 | X4P-001, an orally bioavailable CXCR4 antagonist, increases immune cell infiltration and tumor inflammatory status in the microenvironment of melanoma | Robert Andtbacka, MD Huntsman Cancer Institute, Salt Lake City, UT, USA |
| P54 | Adenosine signature genes associate with tumor regression in renal cell carcinoma (RCC) patients treated with the adenosine A2A receptor (A2AR) antagonist, CPI-444 | Andrew Hotson, PhD Corvus Pharmaceuticals, Burlingame, CA, USA |
| P67 | Innovative combinatorial approach to characterize the immune landscape and analyze the tumor response after anti-PD-1 blockade in a 3D ex-vivo tumoroid system of non-small cell lung cancer | Melba Marie Page, PhD Nilogen Oncosystems, Tampa, FL, USA |
| P87 | Preliminary evidence of intratumoral activation and immunomodulatory effect of CX-072, a Probody therapeutic antibody prodrug targeting PD-L1, in a phase 1/2a trial | Luc R. Desnoyers, PhD CytomX Therapeutics, Inc., South San Francisco, CA, USA |
| P113 | Digital spatial profiling of bone-marrow infiltrating immune cells in acute myeloid leukemia | Sergio Rutella, MD, PhD Nottingham Trent University, Nottingham, UK |
| P131 | High-plex predictive marker discovery for melanoma immunotherapy treated patients using NanoString® Digital Spatial Profiling | David Rimm, MD, PhD Yale University School of Medicine, New Haven, CT, USA |
| P136 | Genetic immunosignatures associate with progression-free survival in advanced soft tissue sarcoma patients treated on a Phase 2 trial of the VEGF receptor inhibitor axitinib plus pembrolizumab | Breelyn Wilky, MD University of Miami – SCCC, Miami, FL, USA |
| P139 | “Pharmacodynamic effects of CA170, a first-in-class small molecule oral immune checkpoint inhibitor (ICI) dually targeting V-domain Ig suppressor of T-cell | Funda Meric-Bernstam, MD MD Anderson Cancer Center, Houston, USA |
| P327 | Higher dose single-agent intratumoral G100 (a TLR4 agonist) results in increased biomarker activity and improved clinical outcomes in patients with follicular lymphoma | Ahmad Halwani, MD Huntsman Cancer Institute, Salt Lake City, UT, USA |
| P349 | Spatial distribution analysis reveals increased PD1 expression on cytotoxic T cells leading to tumor regression upon combined MEK and HDAC inhibition in spontaneous PDAC mouse model | Phyllis Cheung, PhD University Hospital Essen, DKFZ, Essen, Germany |
| P354 | Co-clinical trials of MEK inhibitor, anti PD-L1 and anti CTLA-4 combination treatment in Non-Small Cell Lung Cancer | Pierre-Olivier Gaudreau MD Anderson Cancer Center, Houston, USA |
| P360 | Enhanced anti-tumor efficacy of mesothelin-targeted immunotoxin LMB-100 combined with anti-PD-1 antibody | Qun Jiang, PhD National Institutes of Health, Bethesda, MD, USA |
| P389 | Digital spatial profiling on uveal melanoma tissue treated with combined radiofrequency ablation and ipilimumab | Trieu My Van, PhD NKI/Nanostring, Amsterdam, Netherlands |
| P428 | Spatially-resolved, high-plex digital profiling enables characterization of complex immune biology of the colorectal cancer microenvironment | Sarah Church, PhD NanoString Technologies, Seattle, WA, USA |
| P429 | Integrative spatially-resolved, high-plex digital profiling enables characterization of complex immune biology in the tumor microenvironment of mesothelioma | Carmen Ballesteros Merino, PhD, Providence Portland Cancer Center, Portland, OR, USA |
| P450 | The stapled peptide ALRN-6924, a dual inhibitor of MDMX and MDM2, displays immunomodulatory activity and enhances immune checkpoint blockade in syngeneic mouse models | Luis Carvajal, PhD Aileron Therapeutics, Inc., Cambridge, MA, USA |
| P460 | Chemotherapy induced immunogenic cell death and response to STING agonist in high-grade serous ovarian cancer | Sarah Nersesian, MSc Queen’s University, Kingston, ON, Canada |
| P468 | Transcriptomic profiles conducive to immune-mediated tumor rejection in human breast cancer skin metastases treated with Imiquimod | Mariya Rozenblit, MD Yale University, Connecticut, CT, USA |
| P564 | Interleukin-6 gene expression is highly upregulated in immune checkpoint mediated enterocolitis | Daniel Johnson, MD MD Anderson Cancer Center, Houston, TX, USA |
| P597 | Reovirus infection of prostate cancer induces upregulation of the negative regulators PD-L1 and BTLA | Nicola Annels, PhD The University of Surrey, Guildford, UK |
| P614 | Nano-Pulse Stimulation™ of murine melanoma and mammary carcinoma is a physical modality that eliminates the treated tumor by regulated cell death and induces innate and adaptive immune responses | Amanda McDaniel, BA Pulse Biosciences, Burlingame, CA, USA |
| P650 | Selective CD47 immune checkpoint targeting on tumor cells modulates the tumor microenvironment to enhance macrophage tumoricidal function | Vanessa Buatois, PhD Novimmune SA, Geneva, Switzerland |
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