GeoMx DSP: Your Guide to Spatial Biology
The GeoMx Digital Spatial Profiler (DSP) provides morphological context in spatial transcriptomics and spatial proteomics experiments from just one slide.
From discovery to translational research, the GeoMx DSP is the most flexible and robust spatial biology solution designed to conform to your ever-changing research needs.
Imagine the Possibilities with GeoMx DSP
Heterogeneity. Resolved.
Spatially resolve tissues and cell populations with functional segmentation.
Detect more.
Without compromise.
Detect more of the transcriptome and proteome with the highest plex and highest sensitivity.
Consistent results. Reliable answers.
Multi-sample analysis and cohort studies made easy with unmatched reproducibility and scalability.
Unlock your samples. With confidence.
Get proven, robust results from FFPE, FF tissues and TMAs using standard histology workflows.
Structure dictates function. Think outside the box.
Profile functionally distinct cells and structures to get a complete picture of the biology that matters.
Analyze today.
Publish faster.
Don’t wait. Get publication-ready results faster with higher throughput and an integrated data analysis software.
How it Works
The GeoMx DSP workflow seamlessly integrates with current histology or genomics workflows to help researchers obtain robust and reproducible spatial multiomics data quickly.
Whole tissue sections, FFPE or fresh frozen, can be imaged and stained for RNA or protein. Researchers can then precisely select which tissue compartments or cell types to profile based on the biology, and subsequently count expression levels using either the nCounter Analysis System or an Illumina Sequencer.
Biology-driven Profiling – Spatial Genomics
Capture tissue heterogeneity through flexible profiling
Geometric Profiling
Segmentation
Cell Type Specific
Contour
Gridded
What is the heterogeneity of expression in different regions of my tissue?
What is the expression profile of distinct biological compartments (e.g., Tumor-TME)?
What is the expression profile of a specific cell population in my tissue?
How does the immune environment change on either side of an infiltrate boundary?
What novel targets are uncovered with deep mapping of a specific tissue region?
GeoMx Publications
Neoadjuvant enoblituzumab in localized prostate cancer: a single-arm, phase 2 trial
B7 homolog 3 (B7-H3; CD276), a tumor-associated antigen and possible immune checkpoint, is highly expressed in prostate cancer (PCa) and is associated with early recurrence and metastasis. Enoblituzumab is a humanized, Fc-engineered, B7-H3-targeting antibody that mediates antibody-dependent cellular cytotoxicity.
New technologies to study helminth development and host-parasite interactions
How parasites develop and survive, and how they stimulate or modulate host immune responses are important in understanding disease pathology and for the design of new control strategies. Microarray analysis and bulk RNA sequencing have provided a wealth of data on gene expression as parasites develop through different life-cycle stages and on host cell responses to infection.
Digital spatial profiling of intraductal papillary mucinous neoplasms: Toward a molecular framework for risk stratification
The histopathologic heterogeneity of intraductal papillary mucinous neoplasms (IPMN) complicates the prediction of pancreatic ductal adenocarcinoma (PDAC) risk. Intratumoral regions of pancreaticobiliary (PB), intestinal (INT), and gastric foveolar (GF) epithelium may occur with either low-grade dysplasia (LGD) or high-grade dysplasia (HGD).
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