GeoMx® Discovery Proteome Atlas | Bruker Spatial Biology

More biology. More discovery.

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Unmatched biomarker discovery with 1200+ spatially resolved proteins and single-cell resolution

The GeoMx Discovery Proteome Atlas (DPA) is the highest-plex, commercially available antibody-based spatial proteomics assay, investigating the expression of over 1200 proteins with single-cell resolution. Designed for unprecedented translational discovery with the GeoMx Digital Spatial Profiler (DSP), this curated selection of 1200+ pre-validated human targets spans key cell signaling and disease pathways. Identify new biomarker and drug target candidates by quantifying more proteins than ever before—within your existing GeoMx workflow.

Each antibody clone is sourced from Abcam’s IHC-validated collection and further optimized for spatial profiling, giving you a straightforward path to verify and validate biomarker candidates downstream of GeoMx DSP. Paired with high-throughput, regionally focused sequencing readout, GeoMx DPA maximizes data yield per sample, helping researchers conserve tissue while accelerating discovery.

How it Works

The GeoMx Discovery Proteome Atlas (DPA) enables spatial detection of over 1200 human protein targets—the highest commercially available plex among antibody-based spatial assays. Designed for advanced translational research, GeoMx DPA provides scientifically curated content for use across oncology, immunology, and neuroscience.

01:

Validated and Translationally Ready

Every target in GeoMx DPA is a rigorously vetted RabMab® antibody from Abcam, enabling highly reproducible, spatially resolved data and seamless downstream validation with IHC or IF.

02:

Measure 130+ Post-Translational Modifications in situ

Interrogate phosphorylation, glycosylation, ubiquitination, and more to reveal active signaling states missed by transcriptomics.

03:

Cover 40+ Tissues, 120+ Biological Processes, and 29 Functional Annotations

Explore broad biological and disease relevance with a panel designed to support biomarker discovery across diverse tissue types, mechanistic pathways, and research areas including cancer, immunology, and neurobiology.

04:

Resolve Protein Expression at Single-Cell Resolution

Spatially resolve proteins ranging from tumor niches to rare cell populations to single cells.

05:

Integrate Multiomics with GeoMx RNA Assays

Combine GeoMx DPA with GeoMx Whole Transcriptome Atlas (WTA) to profile 1200+ proteins and 18,000+ RNAs to enable cross-modality biomarker discovery within the same region of interest.

06:

Customize with Additional Antibodies to Expand Discovery

Easily tailor GeoMx DPA for your specific research needs by adding up to 40 user-selected targets through the GeoMx Protein Barcoding Service (PBS).

Applications

Empower Biomarker Discovery

Unmatched Protein Plex at the Single-Cell Level

Enable Spatial Multiomics

Empower Biomarker Discovery

More biology. More targets. More potential.

Built as an expansion of the GeoMx IO Proteome Atlas (IPA), GeoMx DPA now enables spatial resolution of over 1200 protein targets—including markers across 40+ tissues, 120+ disease-relevant annotations, and 130+ post-translational modifications. Dive deeper into the pathways that drive disease and uncover novel biomarker candidates for therapeutic development.

Unmatched Protein Plex at the Single-Cell Level

Investigate the expression of 1200+ proteins on enriched rare cells.

A, Single-cell segmentation to investigate the expression of 1200+ proteins on enriched rare AT8+ and AT8- cells. B, Proof-of-concept experiment showing a Region of Interest (ROI) drawn around a single HS578T cell enabling the detection of 412 proteins. As expected, enrichment of 10 cells within a single ROI resulted in higher target detection (650+).

Enable Spatial Multiomics

Flexibly layer RNA and protein expression on either serial or same-slide sections.

Combine GeoMx DPA with the GeoMx Whole Transcriptome Atlas to generate spatial multiomic data, measuring over 18,000 transcripts and 1200+ proteins in parallel. This integrated workflow empowers you to correlate transcriptional signals with protein-level function, accelerating discovery of novel mechanisms, biomarkers, and therapeutic targets.