
OLD Category: immunology
August 21, 2023 / Immunology
A robust platform for integrative spatial multi-omics analysis to map immune responses to SARS-CoV-2 infection in lung tissues
The SARS-CoV-2 (COVID-19) virus has caused a devastating global pandemic of respiratory illness. To understand viral pathogenesis, methods are available for studying dissociated cells in blood, nasal samples, bronchoalveolar lavage…
August 17, 2023 / Lancet
Immune response after pig-to-human kidney xenotransplantation: a multimodal phenotyping study
Background: Cross-species immunological incompatibilities have hampered pig-to-human xenotransplantation, but porcine genome engineering recently enabled the first successful experiments. However, little is known about the immune response after the transplantation of…
August 1, 2023 / JCI Insight
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease
Cutaneous lupus erythematosus (CLE) is a disfiguring autoimmune skin disease characterized by an inflammatory infiltrate rich in T cells, which are strongly implicated in tissue damage. How these cells adapt…
July 26, 2023 / Nat Commun
Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease
Ulcerative colitis and Crohn's disease are chronic inflammatory intestinal diseases with perplexing heterogeneity in disease manifestation and response to treatment. While the molecular basis for this heterogeneity remains uncharacterized, single-cell…
July 13, 2023 / iScience
Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia
The COVID-19 pandemic continues to be a health crisis with major unmet medical needs. The early responses from airway epithelial cells, the first target of the virus regulating the progression…
July 11, 2023 / J Exp Med
Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice
Immune-related adverse events (irAEs) are a notable complication of PD-1 cancer immunotherapy. A better understanding of how these iatrogenic diseases compare with naturally arising autoimmune diseases is needed for treatment…
July 7, 2023 / J Biol Chem
Nicotinamide N-methyltransferase Mediates Lipofibroblast-Myofibroblast Transition and Apoptosis Resistance
Metabolism controls cellular phenotype and fate. In this report, we demonstrate that nicotinamide N-methyltransferase (NNMT), a metabolic enzyme that regulates developmental stem cell transitions and tumor progression, is highly expressed…
June 29, 2023 / J Clin Invest
Active transcription in the vascular bed characterizes rapid progression in idiopathic pulmonary fibrosis
Idiopathic Pulmonary Fibrosis (IPF) is the most common manifestation of interstitial lung disease (ILD), with a median survival of 3-5 years after diagnosis. IPF is characterized by progressive fibrosis with…
June 27, 2023 / Nat Commun
In vivo inhibition of nuclear ACE2 translocation protects against SARS-CoV-2 replication and lung damage through epigenetic imprinting
In vitro, ACE2 translocates to the nucleus to induce SARS-CoV-2 replication. Here, using digital spatial profiling of lung tissues from SARS-CoV-2-infected golden Syrian hamsters, we show that a specific and…
June 16, 2023 / Sci Adv
Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response
Biomedical devices comprise a major component of modern medicine, however immune-mediated fibrosis and rejection can limit their function over time. Here, we describe a humanized mouse model that recapitulates fibrosis…
June 8, 2023 / J Inflamm Res
The Technical Feasibility of Digital Spatial Profiling in Immune/Inflammation Study of Thrombosis
Background: A comprehensive study of the distribution and role of immune/inflammatory cells in thrombosis is still lacking because traditional pathology techniques cannot accomplish the analysis of numerous protein and genetic…
June 6, 2023 / J Hepatol
Morphologic and molecular analysis of liver injury after SARS-CoV-2 vaccination reveals distinct characteristics
Background and Aims: Liver injury after COVID-19 vaccination is very rare and shows clinical and histomorphological similarities with autoimmune hepatitis (AIH). Little is known about the pathophysiology of COVID-19 vaccine-induced…