Category: signatures

October 3, 2023 / Cell Rep

  • Ng AHC, Hu H, Wang K, Scherler K, Warren SE, Zollinger DR, McKay-Fleisch J, Sorg K, Beechem JM, Ragaglia E, Lacy JM, Smith KD, Marshall DA, Bundesmann MM, Lopez de Castilla D, Corwin D, Yarid N, Knudsen BS, Lu Y, Goldman JD, Heath JR
Local immune activation at mucosal surfaces, mediated by mucosal lymphoid tissues, is vital for effective immune responses against pathogens. While pathogens like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can…
September 30, 2023 / Alzheimers Dement

  • Walker JM, Orr ME, Orr TC, Thorn EL, Christie TD, Yokoda RT, Vij M, Ehrenberg AJ, Marx GA, McKenzie AT, Kauffman J, Selmanovic E, Wisniewski T, Drummond E, White CL 3rd, Crary JF, Farrell K, Kautz TF, Daoud EV, Richardson TE
INTRODUCTION: Alzheimer's disease (AD) and primary age-related tauopathy (PART) both harbor 3R/4R hyperphosphorylated-tau (p-tau)-positive neurofibrillary tangles (NFTs) but differ in the spatial p-tau development in the hippocampus. METHODS: Using Nanostring…
September 27, 2023 / Cancer Res Commun

  • Ye J, Guo W, Wang C, Egelston CA, D'Apuzzo M, Shankar G, Fakih MG, Lee PP
Microsatellite stable (MSS) colorectal cancer (CRC) patients with liver metastases are resistant to immune checkpoint inhibitor (ICI) therapy, while about one-third of CRC patients without liver metastases, particularly those with…
September 27, 2023 / Oncoimmunology

  • Martinez-Morilla S, Myrto Moutafi, Aileen I. Fernandez, Shlomit Jessel, Prajan Divakar, Pok Fai Wong, Rolando Garcia-Milian, Kurt A. Schalper, Harriet M. Kluger & David L. Rimm
Although immune checkpoint inhibitor (ICI) therapy has dramatically improved outcome for metastatic melanoma patients, many patients do not benefit. Since adverse events may be severe, biomarkers for resistance would be…
September 27, 2023 / Gut

  • O'Rourke CJ, Salati M, Rae C, Carpino G, Leslie H, Pea A, Prete MG, Bonetti LR, Amato F, Montal R, Upstill-Goddard R, Nixon C, Sanchon-Sanchez P, Kunderfranco P, Sia D, Gaudio E, Overi D, Cascinu S, Hogdall D, Pugh S, Domingo E, Primrose JN, Bridgewater J, Spallanzani A, Gelsomino F, Llovet JM, Calvisi DF, Boulter L, Caputo F, Lleo A, Jamieson NB, Luppi G, Dominici M, Andersen JB, Braconi C
Objective: Cytotoxic agents are the cornerstone of treatment for patients with advanced intrahepatic cholangiocarcinoma (iCCA), despite heterogeneous benefit. We hypothesised that the pretreatment molecular profiles of diagnostic biopsies can predict…
September 26, 2023 / Clin Cancer Res

  • Bessede A, Peyraud F, Le Moulec S, Cousin S, Cabart M, Chomy F, Rey C, Lara O, Odin O, Nafia I, Guégan JP, Italiano A
Purpose: Overexpression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1) has been reported in several tumor types, including NSCLC, and has been shown to promote tumor immune evasion and inhibit…
September 26, 2023 / Cancer

  • Riedinger CJ, Esnakula A, Haight PJ, Suarez AA, Chen W, Gillespie J, Villacres A, Chassen A, Cohn DE, Goodfellow PJ, Cosgrove CM
Background: Mismatch-repair (MMR)/microsatellite instability (MSI) status has therapeutic implications in endometrial cancer (EC). The authors evaluated the concordance of testing and factors contributing to MMR expression heterogeneity. Methods: Six hundred…
September 20, 2023 / Neurobiol Dis

  • Israel LL, Oliver Braubach, Ekaterina S. Shatalova, Oksana Chepurna, Sachin Sharma, Dmytro Klymyshyn, Anna Galstyan, Antonella Chiechi, Alysia Cox, David Herman, Bishop Bliss, Irene Hasen, Amanda Ting, Rebecca Arechavala, Michael T. Kleinman, Rameshwar Patil, Eggehard Holler, Julia Y. Ljubimova, Maya Koronyo-Hamaoui, Tao Sun, Keith L. Black
Air pollution poses a significant threat to human health, though a clear understanding of its mechanism remains elusive. In this study, we sought to better understand the effects of various…
September 19, 2023 / Scand J Immunol

  • Ignatov B, Sortebech D, Emmanuel T, Zhuravleva E, Eidsmo L
Specific T cell populations in the skin have been demonstrated as important disease drivers in several dermatoses. Due to the unique skin architecture, these cells are not grouped together in…
September 19, 2023 / Clin Cancer Res

  • Deng N, Reyes-Uribe L, Fahrmann JF, Thoman WS, Munsell MF, Dennison JB, Murage E, Wu R, Hawk ET, Thirumurthi S, Lynch PM, Dieli-Conwright CM, Lazar AJ, Jindal S, Chu K, Chelvanambi M, Basen-Engquist K, Li Y, Wargo JA, McAllister F, Allison JP, Sharma P, Sinha KM, Hanash S, Gilchrist SC, Vilar E
Purpose: Lynch Syndrome (LS) is a hereditary condition with a high lifetime risk of colorectal and endometrial cancers. Exercise is a non-pharmacological intervention to reduce cancer risk, though its impact…
September 15, 2023 / Am J Respir Crit Care Med

  • Yang DC, Hsu SW, Li JM, Oldham J, Chen CH
Idiopathic pulmonary fibrosis (IPF) is characterized by heterogeneity, manifested as patchy lesions evident in histopathologic and radiologic findings of the lung (1). Although current technologies, such as single-cell sequencing and…
September 14, 2023 / Gut

  • van Eijck CWF, Mustafa DAM, Vadgama D, de Miranda NFCC, Groot Koerkamp B, van Tienhoven G, van der Burg SH, Malats N, van Eijck CHJ; Dutch Pancreatic Cancer Group (DPCG)
Background: This study investigates sex disparities in clinical outcomes and tumour immune profiles in patients with pancreatic ductal adenocarcinoma (PDAC) who underwent upfront resection or resection preceded by gemcitabine-based neoadjuvant…