BOND RX & NanoString
GeoMx® Digital Spatial Profiler
Automated High Plex Profiling
Understanding tissue heterogeneity across meaningful cohorts is critical to answering key biological questions in translational research. The NanoString GeoMx® Digital Spatial Profiler (DSP) and BOND RX Fully Automated Research Stainer from Leica Biosystems workflow enable automated slide staining with minimal hands-on time to complete projects in the least amount of time. Automate sample preparation, morphology marker staining, and high plex protein or gene expression profiling to leave more time to explore the spatial biology of your samples.
Get more data in a day with automation
- Reduce sample prep hands-on time to 30 minutes
- Prepare any sample type including FFPE and fresh frozen
- Decrease technical variation between samples with reduced manual steps
- Time runs to fit your schedule
- Run up to 30 samples on the Bond RX/RXm
- Limited exposure to hazardous dewaxing materials
Discover more Spatial Biology with the BOND RX
The BOND RX Fully Automated Research Stainer from Leica Biosystems provides superior quality and flexibility whilst enabling the automation of GeoMx DSP sample preparation. The flexible modular design fits a range of sample types and morphology marker staining protocols. Slide preparation for the NanoString GeoMx RNA and Protein assays are compatible on the BOND RX/BOND RXm. The modular nature of the Fully Automated Research Stainers from Leica Biosystems provides flexibility and supports a broad range of research needs.
Activin A-mediated polarization of cancer-associated fibroblasts and macrophages confers resistance to checkpoint immunotherapy in skin cancer
Purpose: Cemiplimab is approved for the treatment of locally advanced basal cell carcinomas (BCCs), however with mitigated results. We sought to interrogate the cellular and molecular transcriptional reprogramming underlying BCC resistance to immunotherapy.
Harnessing the potential of spatial multiomics: a timely opportunity
In a recent publication in Nature,1 Zhang et al. have developed spatial ATAC-RNA-seq and spatial CUT&Tag-RNA-seq as innovative tools that enable the high-resolution mapping of epigenetic and transcriptomic features in cells from frozen tissue sections.
Two Cases of Severe Pulmonary Toxicity from Highly Active Mesothelin-Directed CAR T Cells
Multiple clinical studies have treated mesothelin (MSLN)-positive solid tumors by administering MSLN-directed chimeric antigen receptor (CAR) T cells. Although these products are generally safe, efficacy is limited.