BOND RX & NanoString
GeoMx® Digital Spatial Profiler
Automated High Plex Profiling
Understanding tissue heterogeneity across meaningful cohorts is critical to answering key biological questions in translational research. The NanoString GeoMx® Digital Spatial Profiler (DSP) and BOND RX Fully Automated Research Stainer from Leica Biosystems workflow enable automated slide staining with minimal hands-on time to complete projects in the least amount of time. Automate sample preparation, morphology marker staining, and high plex protein or gene expression profiling to leave more time to explore the spatial biology of your samples.
Get more data in a day with automation
- Reduce sample prep hands-on time to 30 minutes
- Prepare any sample type including FFPE and fresh frozen
- Decrease technical variation between samples with reduced manual steps
- Time runs to fit your schedule
- Run up to 30 samples on the Bond RX/RXm
- Limited exposure to hazardous dewaxing materials
Discover more Spatial Biology with the BOND RX
The BOND RX Fully Automated Research Stainer from Leica Biosystems provides superior quality and flexibility whilst enabling the automation of GeoMx DSP sample preparation. The flexible modular design fits a range of sample types and morphology marker staining protocols. Slide preparation for the NanoString GeoMx RNA and Protein assays are compatible on the BOND RX/BOND RXm. The modular nature of the Fully Automated Research Stainers from Leica Biosystems provides flexibility and supports a broad range of research needs.
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GeoMx Publications
Assessing Longitudinal Treatment Efficacies and Alterations in Molecular Markers Associated with Glutamatergic Signaling and Immune Checkpoint Inhibitors in a Spontaneous Melanoma Mouse Model
Previous work done by our laboratory described the use of an immunocompetent spontaneous melanoma-prone mouse model, TGS (TG-3/SKH-1), to evaluate treatment outcomes using inhibitors of glutamatergic signaling and immune checkpoint for 18 weeks. We showed a significant therapeutic efficacy with a notable sex-biased response in male mice.
Spatial transcriptomics reveals molecular dysfunction associated with cortical Lewy pathology
A key hallmark of Parkinson’s disease (PD) is Lewy pathology. Composed of α-synuclein, Lewy pathology is found both in dopaminergic neurons that modulate motor function, and cortical regions that control cognitive function.
Digital spatial profiling identifies molecular changes involved in development of colitis-associated colorectal cancer
Objective: Chronic colonic inflammation seen in inflammatory bowel disease (IBD) is a risk factor for colorectal cancer (CRC). Colitis-associated cancers (CAC) are molecularly different from sporadic CRC.
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