Spatial transcriptomics for characterisation of advanced cancer models
Join us for this webinar, co-sponsored between NanoString and Illumina as we delve into the use of spatial transcriptomics in the study and application of Patient Derived Explants (PDEs).
The Centre for 3D Models of Health and Disease at UCL develops a range of 3D bioengineered and patient derived models of cancer. Advances in spatial transcriptomics including NanoString’s GeoMx DSP Cancer Transcriptome Atlas and Whole Transcriptome Atlas have allowed to us to characterise our models in depth, understanding the complex interplay between cancer cells and the tumour microenvironment.
Here Dr Heavey presents data on the spatial landscape of prostate cancer in Patient Derived Explants (PDEs) versus matched radical prostatectomy specimens, as well as exploring the effects of a panel of targeted therapies on these PDEs, and separately unveil the tumour-stroma boundary in a novel bioengineered model of ameloblastoma.