Unravelling the secrets of Infectious Diseases – in bulk and spatially
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The threat of infectious disease has become ever more apparent with the outbreak of the COVID-19 pandemic. Infected samples are complex and usually dominated by host cells, making pathogen detection a challenge. Disease severity and morbidity can be confounded by underlying conditions and/or an abnormal immune response. Efficient and robust techniques are needed to track transcriptional and proteomic changes from a variety of sample types. Borrowing lessons from immuno-oncology, Researchers are learning to treat disease by addressing the host as well as the pathogen, modulating the immune system to fine tune the host response and avoid systemic hyperinflammation and organ damage. In this talk we will be introducing you to NanoString’s toolbox of high-plex gene expression panels and proteomic assays across both the nCounter® and GeoMx® Digital Spatial Profiling (DSP) platforms that can be used with multiple sample types, including Formalin-Fixed, Paraffin-Embedded (FFPE) tissue sections. nCounter Host Response Panel for human and mouse enabling research on pathogenesis and the host response in both humans and mouse models organisms allows you to profile 785 genes in human or mouse genes across 50+ pathways. You can detect the presence of a pathogen and evaluate organ-specific tissue damage with a Panel Plus spike-in of up to 55 genes. Using the GeoMx DSP RNA and Protein assays, tissue samples with the host immune content can be spatially profiled. NanoString’s nCounter Analysis System and GeoMx Digital Spatial Profiler (DSP) help you unravelling the secrets of Infectious Diseases – in bulk and spatially.