High Resolution Spatial Proteomic Analysis
The CosMx™ Human Immuno-Oncology Protein Panel enables high-plex spatial analysis of more than 64 proteins from a single FFPE slide at subcellular resolution. Profile expression of different Immune and Oncology-related proteins to get a comprehensive view of the spatial phenotyping landscape, including tissue heterogeneity, signaling pathways, and tumor progression.
The CosMx™ SMI and decoder probes are not offered and/or delivered to the Federal Republic of Germany for use in the Federal Republic of Germany for the detection of cellular RNA, messenger RNA, microRNA, ribosomal RNA and any combinations thereof in a method used in fluorescence in situ hybridization for detecting a plurality of analytes in a sample without the consent of the President and Fellows of Harvard College (Harvard Corporation) as owner of the German part of EP 2 794 928 B1. The use for the detection of cellular RNA, messenger RNA, microRNA, ribosomal RNA and any combinations thereof is prohibited without the consent of the President and Fellows of Harvard College (Harvard Corporation).
The CosMx™ SMI and decoder probes are not offered and/or delivered to the following UPC member states* for use in these countries for the detection of RNA in a method used for the detection of a plurality of analytes in a cell or tissue sample without the consent of the President and Fellows of Harvard College (Harvard Corporation) as owner of the Unitary Patent EP 4 108 782 B1. The use for the detection of RNA is prohibited without the consent of the President and Fellows of Harvard College (Harvard Corporation).
* Austria, Belgium, Bulgaria, Denmark, Estonia, Finland, France, Germany, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Portugal, Slovenia, Sweden
How it works
The CosMx Protein Assays rely on antibodies coupled to unique oligonucleotide tags designed for an imaging-based readout on the CosMx™ Spatial Molecular Imager (SMI). CosMx SMI is an integrated system with cyclic fluorescent chemistry, high-resolution imaging, interactive data analysis and visualization software. This imaging-based readout yields a series of fluorescent protein images to provide relative protein abundance at single cell and subcellular resolution. All CosMx Protein assays undergo extensive antibody validation to ensure high quality data.
Unique view of the spatial protein expression for tumor and immune response to enable cell profiling of immune and non-immune cells, including T cells, B cells, macrophages, NK cells, epithelia and stroma
Characterize Disease Biology
Includes markers to monitor immune activation, cytotoxicity, and key IO drug targets
Highly Curated Content
Content developed by industry experts
Customize with up to 8 additional protein targets of your choice
Get more accurate cell segmentation with dedicated cell membrane and nuclear markers