BOND RX & NanoString
GeoMx® Digital Spatial Profiler
Automated High Plex Profiling
Understanding tissue heterogeneity across meaningful cohorts is critical to answering key biological questions in translational research. The NanoString GeoMx® Digital Spatial Profiler (DSP) and BOND RX Fully Automated Research Stainer from Leica Biosystems workflow enable automated slide staining with minimal hands-on time to complete projects in the least amount of time. Automate sample preparation, morphology marker staining, and high plex protein or gene expression profiling to leave more time to explore the spatial biology of your samples.
Get more data in a day with automation
- Reduce sample prep hands-on time to 30 minutes
- Prepare any sample type including FFPE and fresh frozen
- Decrease technical variation between samples with reduced manual steps
- Time runs to fit your schedule
- Run up to 30 samples on the Bond RX/RXm
- Limited exposure to hazardous dewaxing materials
Discover more Spatial Biology with the BOND RX
The BOND RX Fully Automated Research Stainer from Leica Biosystems provides superior quality and flexibility whilst enabling the automation of GeoMx DSP sample preparation. The flexible modular design fits a range of sample types and morphology marker staining protocols. Slide preparation for the NanoString GeoMx RNA and Protein assays are compatible on the BOND RX/BOND RXm. The modular nature of the Fully Automated Research Stainers from Leica Biosystems provides flexibility and supports a broad range of research needs.
Mapping the Immune Cell Microenvironment with Spatial Profiling in Muscle Tissue Injected with the Venom of Daboia russelii
Pathological and inflammatory events in muscle after the injection of snake venoms vary in different regions of the affected tissue and at different time intervals. In order to study such heterogeneity in the immune cell microenvironment, a murine model of muscle necrosis based on the injection of the venom of Daboia russelii was used.
Phase 2 Trial of Stereotactic Ablative Radiotherapy for Patients with Primary Renal Cancer
Background: Most renal cell carcinomas (RCCs) are localized and managed by active surveillance, surgery, or minimally invasive techniques. Stereotactic ablative radiation (SAbR) may provide an innovative non-invasive alternative although prospective data are limited.
MULTIPLATFORM ANALYSIS OF INTRATUMORAL PTEN HETEROGENEITY IN MELANOMA
Loss of protein expression of the tumor suppressor PTEN is associated with increased cancer aggressiveness, decreased tumor immune infiltration, and resistance to immune and targeted therapies in melanoma. We assessed a unique cohort of 8 melanoma samples with focal loss of PTEN protein expression to understand features and mechanisms of PTEN loss in this disease.
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