nCounter® Autoimmune Discovery Panel

Helping Your Research

The nCounter Autoimmune Discovery Panel is designed to enable researchers to discover links between known autoimmune disease associated germline variants and gene expression. The genes were selected in collaboration with leading autoimmune researchers and are linked to the top nine autoimmune diseases. This panel is made-to-order and you can add on up to 55 gene targets to the panel with the Panel Plus product to customize the panel to your research project.

How it Works

The Human nCounter Autoimmune Discovery Panel is a 770-gene panel that provides analysis of the links between known disease associated mutations and gene expression changes, allowing researchers to identify new gene functions and to look at gene expression in response to treatment. Highlights of the Autoimmune Discovery Panel include:

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Discovery tool for disease-associated mutation gene function studies and biomarker characterization

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Comprehensive content associated with nine autoimmune diseases

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Gene expression profiling of immune response together with gene mutations

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Made-to-order & customizable with the Panel Plus option – add up to 55 user-defined genes

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Simple workflow, user-friendly, and efficient with just 15 minutes total hands-on time

Panel Selection Tool

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Product Information

Specifications
Panel Content
Specifications
Panel Content

Coverage of Autoimmune Diseases

Disease-specific annotations for nine autoimmune disease types and human immune response genes were assigned across all genes in the autoimmune discovery panel, allowing for the identification of gene functions and signatures for all autoimmune diseases.

Related Resources

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Product Bulletin Autoimmune Discovery Panel – Product Bulletin
Flyer Autoimmune Publications – Flyer
Webinar Defining the function of genes associated with chronic inflammatory diseases: The nCounter® Autoimmune Discovery Consortium Panel
Webinar Take on the challenges of Autoimmunity research with the nCounter® Analysis System
Blog Post Characterizing Severe Autoimmune Toxicities Associated with Checkpoint Inhibitor Therapies

Publications

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Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.

The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required.

Gene Expression Analysis in Four Dogs With Canine Pemphigus Clinical Subtypes Reveals B Cell Signatures and Immune Activation Pathways Similar to Human Disease.

Pemphigus is a group of autoimmune-mediated mucocutaneous blistering diseases characterized by acantholysis. Pemphigus has also been recognized in dogs and shares similar clinical characteristics and variants with human pemphigus.

Genetic in situ engineering of myeloid regulatory cells controls inflammation in autoimmunity.

The ability of myeloid regulatory cells (MRCs) to control immune responses and to promote tolerance has prompted enormous interest in exploiting them therapeutically to treat inflammation, autoimmunity, or to improve outcomes in transplantation. While immunomodulatory small-molecule compounds and antibodies have provided relief for some patients, the dosing entails high systemic drug exposures and thus increased risk of off-target adverse effects.

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