nCounter® Autoimmune Discovery Panel

Helping Your Research

The nCounter Autoimmune Discovery Panel is designed to enable researchers to discover links between known autoimmune disease associated germline variants and gene expression. The genes were selected in collaboration with leading autoimmune researchers and are linked to the top nine autoimmune diseases.

This panel is a Curated Gene List: application and pathway-specific content pre-designed and developed by NanoString available for custom ordering. You can add up to 55 gene targets to it with a “Plus” option to customize the panel to your research project.

How it Works

The Human nCounter Autoimmune Discovery Panel is a 770-gene panel that provides analysis of the links between known disease associated mutations and gene expression changes, allowing researchers to identify new gene functions and to look at gene expression in response to treatment. Highlights of the Autoimmune Discovery Panel include:


Discovery tool for disease-associated mutation gene function studies and biomarker characterization


Comprehensive content associated with nine autoimmune diseases


Gene expression profiling of immune response together with gene mutations


Curated gene list available for custom ordering, customizable “Plus” option to add up to 55 user-defined genes


Simple workflow, user-friendly, and efficient with just 15 minutes total hands-on time

Panel Selection Tool

Find the gene expression panel for your research with Panel Pro

Find Your Panel

Product Information

Panel Content
Panel Content

Coverage of Autoimmune Diseases

Disease-specific annotations for nine autoimmune disease types and human immune response genes were assigned across all genes in the autoimmune discovery panel, allowing for the identification of gene functions and signatures for all autoimmune diseases.

Related Resources

See All Resources
Product Bulletin Autoimmune Discovery Panel – Product Bulletin
Flyer Autoimmune Publications – Flyer
Blog Post Characterizing Severe Autoimmune Toxicities Associated with Checkpoint Inhibitor Therapies
Manual/Instructions NanoU Training Videos


View All Publications

Conjunctival transcriptomics in ocular mucous membrane pemphigoid

PURPOSE: Ocular Mucous Membrane Pemphigoid (OcMMP) is an orphan disease characterized by chronic autoimmune-driven conjunctival inflammation leading to progressive scarring, debilitating symptoms, and blinding sequelae. This feasibility study aims to demonstrate conjunctival genetic transcriptomic analyses as a putative tool for interrogation of pathogenic signaling pathways in OcMMP.

Preclinical Evidence for the Glucocorticoid-Sparing Potential of a Dual Toll-Like Receptor 7/8 Inhibitor in Autoimmune Diseases

Toll-like receptor (TLR) 7 and TLR8 are single-stranded RNA-sensing endosomal pattern recognition receptors that evolved to defend against viral infections. However, aberrant TLR7/8 activation by endogenous ligands has been implicated in the pathogenesis of autoimmune diseases including systemic lupus erythematosus.

Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73

The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required.

Request a Quote

Contact our helpful experts and we’ll be in touch soon.