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nCounter® Myeloid Innate Immunity Panel

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Helping Your Research

The nCounter® Myeloid Innate Immunity Panel provides comprehensive coverage of myeloid-derived cells in a targeted gene expression assay. These panels can be used with multiple sample types like peripheral blood mononuclear cells (PBMCs) or formalin-fixed paraffin-embedded (FFPE) tissue sections and provide results in less than 24 hours with minimal hands-on time and data analysis.  

The Myeloid Innate Immunity Panel is designed to encompass all aspects of the innate immune response of myeloid-derived cells and can be used for basic and translational research in immuno-oncology, autoimmunity, and infectious disease. The panel is curated to include the most current and relevant genes and is available in both human and mouse versions. Use the Myeloid Innate Immunity Panel to study: 

  • Mechanisms of immune evasion
  • Damage response, wound healing & tissue repair 
  • Immune regulation 
  • Disease pathogenesis 
  • Treatment response vs. non-response
Myeloid Innate Immunity

How It Works

The nCounter Myeloid Innate Immunity Panels were developed in collaboration with leading experts in the field of immuno-oncology but can be used to study the role of myeloid-derived cells whenever the innate immune system is implicated in the response to a disease or pathogen. Each panel enables characterization of the innate immune response by profiling genes involved in the recruitment and activation of selected myeloid subtypes.

01:

770 genes In 19 different pathways and processes across 7 different myeloid cell types

02:

Rapidly analyze Complex immune responses with publication-quality results next day

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Optimized for difficult sample types including FFPE, PBMCs, or FACS sorted cells

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Genes represent all major myeloid cell types including neutrophils, eosinophils, mast cells, dendritic cells, monocytes, and macrophages with 19 functional and pathway annotations

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Customize with Panel Plus to spike-in up to 55 genes of your choice to tailor the panel for your research project

Panel Selection Tool

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Product Information

Specifications
Catalog Information
Specifications
Catalog Information

Related Resources

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Product Bulletin Myeloid Innate Immunity Panel – Product Bulletin
Poster AACR 2017 Poster_ Validation of human and mouse myeloid panels on the NanoString® nCounter® Platform

Publications

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Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer.

Purpose: Cancer-associated fibroblasts (CAF) have been implicated as potential mediators of checkpoint immunotherapy response. However, the extensive heterogeneity of these cells has precluded rigorous understanding of their immunoregulatory role in the tumor microenvironment.

Spatial profiling reveals association between WNT pathway activation and T-cell exclusion in acquired resistance of synovial sarcoma to NY-ESO-1 transgenic T-cell therapy.

Background: Genetically engineered T-cell immunotherapies for adoptive cell transfer (ACT) have emerged as a promising form of cancer treatment, but many of these patients develop recurrent disease. Furthermore, delineating mechanisms of resistance may be challenging since the analysis of bulk tumor profiling can be complicated by spatial heterogeneity.

A Novel Artificial Intelligence–Powered Method for Prediction of Early Recurrence of Prostate Cancer After Prostatectomy and Cancer Drivers.

To develop a novel artificial intelligence (AI)–powered method for the prediction of prostate cancer (PCa) early recurrence and identification of driver regions in PCa of all Gleason Grade Group (GGG). MATERIALS AND METHODS: Deep convolutional neural networks were used to develop the AI model.

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