OLD Category: CAR-T
June 12, 2023 / Mol Ther
Two Cases of Severe Pulmonary Toxicity from Highly Active Mesothelin-Directed CAR T Cells
Multiple clinical studies have treated mesothelin (MSLN)-positive solid tumors by administering MSLN-directed chimeric antigen receptor (CAR) T cells. Although these products are generally safe, efficacy is limited. Therefore, we generated…
February 2, 2022 / Clin Transl Immunology
Allogeneic CD20-targeted γδ T cells exhibit innate and adaptive antitumor activities in preclinical B-cell lymphoma models
October 14, 2021 / Commun Biol
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73
August 24, 2021 / J Blood Med
Assessing and Management of Neurotoxicity After CAR-T Therapy in Diffuse Large B-Cell Lymphoma
May 13, 2021 / J Transl Genet Genom