OLD Category: GeoMx DSP

April 17, 2023 / Int J Biol Sci

  • Wang L, Wang D, Zeng X, Zhang Q, Wu H, Liu J, Wang Y, Liu G, Pan Y
The heterogeneity of nasopharyngeal carcinoma (NPC) leads to mixed clinical outcomes. We collected 92 regions of interest from 41 biopsies of patients with untreated NPC and obtained their transcripts using…
April 15, 2023 / Acta Neuropathol Commun

  • Najjary S, Kros JM, de Koning W, Vadgama D, Lila K, Wolf J, Mustafa DAM
Metastases in the brain are the most severe and devastating complication of cancer. The incidence of brain metastasis is increasing. Therefore, the need of finding specific druggable targets for brain…
April 14, 2023 / Cancer Res

  • Wood CS, Pennel KAF, Leslie H, Legrini A, Cameron AJ, Melissourgou-Syka L, Quinn JA, van Wyk HC, Hay J, Roseweir AK, Nixon C, Roxburgh CSD, McMillan DC, Biankin AV, Sansom OJ, Horgan PG, Edwards J, Steele CW, Jamieson NB
Strong immune responses in primary colorectal cancer correspond with better patient survival following surgery compared with tumors with predominantly stromal microenvironments. However, biomarkers to identify patients with colorectal cancer liver…
April 13, 2023 / J Neurotrauma

  • Ravi S, Criado-Marrero M, Barroso D, Braga IM, Bolen M, Rubinovich U, Hery GP, Grudny MM, Koren Iii J, Prokop S, Febo M, Abisambra J
Repetitive mild traumatic brain injuries (rmTBI) are serious trauma events responsible for the development of numerous neurodegenerative disorders. A major challenge in developing diagnostics and treatments for the consequences of…
April 13, 2023 / Int J Mol Sci

  • Bellini D, Milan M, Bordin A, Rizzi R, Rengo M, Vicini S, Onori A, Carbone I, De Falco E
Radiological imaging is currently employed as the most effective technique for screening, diagnosis, and follow up of patients with breast cancer (BC), the most common type of tumor in women…
April 11, 2023 / Cancer Res Commun

  • Gavrielatou N, Vathiotis I, Aung TN, Shafi S, Burela S, Fernandez AI, Moutafi M, Burtness B, Economopoulou P, Anastasiou M, Foukas P, Psyrri A, Rimm DL
Programmed cell death protein‐1 (PD-1)-targeted immunotherapy is approved for recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) treatment. Although its efficacy correlates with PD-L1 expression, response is…
April 11, 2023 / J Microbiol Immunol Infect

  • Yu SC, Chen KC, Ruby Huang RYJ
Background: Reactive lymphadenopathies such as toxoplasmosis and cytomegalovirus lymphadenitis are associated with monocytoid cell proliferation. Monocytoid cells are B-lymphocytes with an undetermined subset. Methods: Using digital spatial profiling whole transcriptome…
April 10, 2023 / J Pharm Anal

  • Fangma Y, Mengting Liu, Jie Liao, Zhong Chen, Yanrong Zheng
Recent studies have highlighted spatially resolved multi-omics technologies, including spatial genomics, transcriptomics, proteomics, and metabolomics, as powerful tools to decipher the spatial heterogeneity of the brain. Here, we focus on…
April 10, 2023 / mBio

  • Ng WH, Ling ZL, Kueh AJ, Herold MJ, West NP, King NJC, Mahalingam S, Liu X
Arthritogenic alphaviruses such as Ross River virus (RRV) and Chikungunya virus (CHIKV) are responsible for large-scale epidemics that cause debilitating acute and chronic musculoskeletal diseases. MXRA8 was recently discovered as…
April 8, 2023 / Am J Transplant

  • Lee CAA, Diana Wang, Martin Kauke-Navarro, Eleanor Russell-Goldman, Shuyun Xu, Kyla N. Mucciarone, Sadaf Sohrabi, Christine G. Lian, Bohdan Pomahac, George F. Murphy
Vascularized composite allografts (VCAs) of faces and extremities are subject to chronic rejection that is incompletely understood. Here we report on immunoproteomic evaluation of a full facial VCA removed 88…
April 7, 2023 / Adv Sci (Weinh)

  • Park HE, Jo SH, Lee RH, Macks CP, Ku T, Park J, Lee CW, Hur JK, Sohn CH
Spatial transcriptomics is a newly emerging field that enables high-throughput investigation of the spatial localization of transcripts and related analyses in various applications for biological systems. By transitioning from conventional…
April 7, 2023 / Immuno-Oncology and Technology

  • Nabhan M, Donagh Egan, Martina Kreileder, Vadim Zhernovkov, Elina Timosenko, Timothy Slidel, Simon Dovedi, Kate Glennon, Donal Brennan, Walter Kolch
Immune checkpoint inhibitors (ICIs), have rejuvenated therapeutic approaches in oncology. Although responses tend to be durable, response rates vary in many cancer types. Thus, the identification and validation of predictive…