OLD Category: methods

May 1, 2023 / Front Oncol

  • Lee RY, Ng CW, Rajapakse MP, Ang N, Yeong JPS, Lau MC
Growing evidence supports the critical role of tumour microenvironment (TME) in tumour progression, metastases, and treatment response. However, the in-situ interplay among various TME components, particularly between immune and tumour…
April 13, 2023 / Int J Mol Sci

  • Bellini D, Milan M, Bordin A, Rizzi R, Rengo M, Vicini S, Onori A, Carbone I, De Falco E
Radiological imaging is currently employed as the most effective technique for screening, diagnosis, and follow up of patients with breast cancer (BC), the most common type of tumor in women…
April 10, 2023 / J Pharm Anal

  • Fangma Y, Mengting Liu, Jie Liao, Zhong Chen, Yanrong Zheng
Recent studies have highlighted spatially resolved multi-omics technologies, including spatial genomics, transcriptomics, proteomics, and metabolomics, as powerful tools to decipher the spatial heterogeneity of the brain. Here, we focus on…
April 8, 2023 / MEGA J Case Rep

  • Yang H, Jiang QH
Background: Non-alcoholic fatty liver disease (NAFLD) is a common type of liver disease and is showing a high prevalence worldwide. The liver fibrosis caused by NAFLD increase the risk of…
April 7, 2023 / Immuno-Oncology and Technology

  • Nabhan M, Donagh Egan, Martina Kreileder, Vadim Zhernovkov, Elina Timosenko, Timothy Slidel, Simon Dovedi, Kate Glennon, Donal Brennan, Walter Kolch
Immune checkpoint inhibitors (ICIs), have rejuvenated therapeutic approaches in oncology. Although responses tend to be durable, response rates vary in many cancer types. Thus, the identification and validation of predictive…
April 7, 2023 / Adv Sci (Weinh)

  • Park HE, Jo SH, Lee RH, Macks CP, Ku T, Park J, Lee CW, Hur JK, Sohn CH
Spatial transcriptomics is a newly emerging field that enables high-throughput investigation of the spatial localization of transcripts and related analyses in various applications for biological systems. By transitioning from conventional…
April 7, 2023 / Eur Heart J

  • de Winther MPJ, Bäck M, Evans P, Gomez D, Goncalves I, Jørgensen HF, Koenen RR, Lutgens E, Norata GD, Osto E, Dib L, Simons M, Stellos K, Ylä-Herttuala S, Winkels H, Bochaton-Piallat ML, Monaco C
The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease…
March 22, 2023 / JID innovations

  • Houser AE, Abiha Kazmi, Arjun K. Nair, Andrew L. Ji
The development of multi-omic profiling tools has rapidly expanded in recent years, along with their use in profiling skin tissues in various contexts, including dermatologic diseases. Among these tools, single-cell…
March 16, 2023 / Int J Parasitol

  • Britton C, Roz Laing, Tom N. McNeilly, Matias G. Perez, Thomas D. Otto, Katie A. Hildersley, Rick M. Maizels, Eileen Devaney, Victoria Gillan
How parasites develop and survive, and how they stimulate or modulate host immune responses are important in understanding disease pathology and for the design of new control strategies. Microarray analysis…
March 3, 2023 / Genome Biol

  • Zhu J, Shang L, Zhou X
Spatially resolved transcriptomics (SRT)-specific computational methods are often developed, tested, validated, and evaluated in silico using simulated data. Unfortunately, existing simulated SRT data are often poorly documented, hard to reproduce,…
March 2, 2023 / Nat Rev Genet

  • Vandereyken K, Sifrim A, Thienpont B, Voet T
The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome from single cells is transforming our understanding of cell biology in health and disease. In less than a decade,…
February 23, 2023 / Transplantation

  • Zubair H, Azim S, Maluf DG, Mas VR, Martins PN
Solid organ transplantation saves thousands of lives suffering from end-stage diseases. Although early transplants experienced acute organ injury, medical breakthroughs, such as tissue typing, and use of immunosuppressive agents have…