Category: toxicology

Comprehensive Mutational and Phenotypic Characterization of New Metastatic Cutaneous Squamous Cell Carcinoma Cell Lines Reveal Novel Drug Susceptibilities.

• Perry J, Ashford B, Thind AS, Gauthier ME, Minaei E, Major G, Iyer NG, Gupta R, Clark J, Ranson M

Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis.

• Hicks ND, Giffen SR, Culviner PH...Sixsmith J, Wolf ID, Fortune SM

Endoplasmic reticulum stress in human chronic wound healing: Rescue by 4‐phenylbutyrate.

• Bachar‐Wikstrom E, Manchanda M, Bansal R, Karlsson M, Kelly‐Pettersson P, Sköldenberg O, Wikstrom JD

Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format.

• Mannhardt I, Saleem U, Mosqueira D...Denning C, Hansen A, Eschenhagen T

The novel glycyrrhetinic acid-tetramethylpyrazine conjugate TOGA induces anti-hepatocarcinogenesis by inhibiting the effects of tumor-associated macrophages on tumor cells.

• Wang X, Tan Y, Zhang Y...Mao Q, Ai C, Hua Q

Water-Pipe Smoking Exposure Deregulates a Set of Genes Associated with Human Head and Neck Cancer Development and Prognosis.

• Lopez-Ozuna VM, Gupta I, Kiow RLC, Matanes E, Kheraldine H, Yasmeen A, Khalil A, Vranic S, Al Moustafa AE, Farsi HFA

Some like it hot: population-specific adaptations in venom production to abiotic stressors in a widely distributed cnidarian.

• Sachkova MY, Macrander J, Surm JM, Aharoni R, Menard-Harvey SS, Klock A, Leach WB, Reitzel AM, Moran Y

A phase Ib open-label dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of cobimetinib (GDC-0973) and ipatasertib (GDC-0068) in patients with locally advanced or metastatic solid tumors.

• Shapiro GI, LoRusso P, Cho DC...Sanabria-Bohorquez S, Meng RD, Bendell JC

Intracellular Fate and Impact on Gene Expression of Doxorubicin/Cyclodextrin-Graphene Nanomaterials at Sub-Toxic Concentration.

• Caccamo D, Curro M, Ientile R...Astilean S, Piperno A, Sciortino MT

Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished TH17 but Enhanced Treg Differentiation.

• Liang J, Ziegler JD, Jahraus B...Hübner K, Balta E, Samstag Y

Xenobiotica-metabolizing enzyme induction potential of chemicals in animal studies: NanoString nCounter gene expression and peptide group-specific immunoaffinity as accelerated and economical substitutions for enzyme activity determinations?

• Riffle B, Oesch F, Heckmanns A, Pötz O, van Ravenzwaay B, Landsiedel R

The GARDpotency Assay for Potency-Associated Subclassification of Chemical Skin Sensitizers—Rationale, Method Development, and Ring Trial Results of Predictive Performance and Reproducibility.

• Gradin R, Johansson A, Forreryd A, Aaltonen E, Jerre A, Larne O, Mattson U, Johansson H