CosMx™ Human Universal Cell Characterization RNA Panel

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Single-Cell Spatial RNA Analysis

The CosMx Universal Cell Characterization Panel is designed to provide robust cell typing, cell-cell interaction analysis, and more in a wide range of tissues and disease states. Profile expression of 1000 highly curated targets at subcellular resolution and customize with up to 50 of your own targets.

The CosMx™ SMI and decoder probes are not offered and/or delivered to the Federal Republic of Germany for use in the Federal Republic of Germany for the detection of cellular RNA, messenger RNA, microRNA, ribosomal RNA and any combinations thereof in a method used in fluorescence in situ hybridization for detecting a plurality of analytes in a sample without the consent of the President and Fellows of Harvard College (Harvard Corporation) as owner of the German part of EP 2 794 928 B1. The use for the detection of cellular RNA, messenger RNA, microRNA, ribosomal RNA and any combinations thereof is prohibited without the consent of the President and Fellows of Harvard College (Harvard Corporation).

How it Works

The CosMx Universal Cell Characterization Panel is a fully-validated RNA assay for the CosMx Spatial Molecular Imager that provides robust tissue mapping, cell typing, and analysis of cell states and interactions on a wide range of tissues and solid tumors.

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Provides robust tissue mapping, cell typing, and analysis of cell states and interactions on a wide range of tissue and organs.

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Reveals interactions between cells including ligand-receptor interactions, interferon response, and signaling pathways such as MAPK, NF-kB, Wnt, and Shh

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Profile states of metabolism, circadian rhythm, antigen presentation, damage, activation, checkpoints, inflammation, proliferation, secretion, stress-response, wound healing, and much more.

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Compatible with up to 50 custom targets as well as up to five CosMx Segmentation Markers

Applications

Segmentation

Cell Typing

Gene Detection

Segmentation

Cell Typing

Gene Detection

Detection of genes of interest in liver cancer

Publications & Posters

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AACR 2024: A single-cell spatially resolved atlas of immune-mediated control of lung adenocarcinoma

High-Plex Spatial Multiomic Technology at the Single-Cell Level in Mouse FFPE Brain Tissue – AGBT 2024

Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma

Synovial sarcoma (SyS) is an aggressive neoplasm driven by the SS18-SSX fusion, and is characterized by low T cell infiltration. Here, we studied the cancer-immune interplay in SyS using an integrative approach that combines single-cell RNA sequencing (scRNA-seq), spatial profiling and genetic and pharmacological perturbations.

The spatial landscape of lung pathology during COVID-19 progression

Recent studies have provided insights into the pathology and immune response to coronavirus disease 2019 (COVID-19)1–8. However, thorough interrogation of the interplay between infected cells and the immune system at sites of infection is lacking.

Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection

The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter-patient and intra-patient heterogeneity of pulmonary virus infection.