Spatial Proteomics Redefined
Comprising nearly all Abcam’s IHC-validated human antibodies for immuno-oncology (IO), the GeoMx IO Proteome Atlas (IPA) is the highest-plex spatial proteomics panel available for FFPE and fresh frozen tissue sections, and enables broad biomarker discovery for translational research. Rapidly discover new protein biomarkers and drug targets by non-destructively profiling over 570 proteins in different tissue compartments such as the tumor, microenvironment, and the immune infiltrate. Get more comprehensive biological information per slide than any traditional immunohistochemistry (IHC) or immunofluorescent (IF) assay yet seamlessly integrate GeoMx IPA into your lab with a histology compatible workflow.
Flex Your Protein Muscles. All 570+ of Them.
Take advantage of the technology behind the GeoMx Digital Spatial Profiler (DSP) that empowers you to enrich for the tissue microenvironments and cell types that matter most to your research and get a more holistic, in situ picture of the biology behind the immune response to cancer and therapeutic response. Explore curated content that includes comprehensive coverage and broad biomarker discovery potential for immunology, oncology, metabolism, epigenetics, and post-translational modifications.
Why Use GeoMx IPA?
Find the next blockbuster IO drug target
Use the GeoMx IO Proteome Atlas to discover the next PD-1 or PD-L1.
Screen the world’s largest catalog of IHC-validated antibodies
Investigate the expression of 570+ human targets on one slide, then take the open-source clone information to Abcam for your downstream IHC validation.
Be the first to discover new multiomic biomarkers
Analyze the expression of the human whole transcriptome (WTA) and IO proteome (IPA) from a single slide using the spatial proteogenomic workflow.
Customize with up to 40 additional protein targets of your choice
Abcam’s IO catalog at your fingertips
Get more information per slide from precious FFPE samples
Rapidly discover new protein biomarkers and drug targets from human samples with unrivaled plex, getting more comprehensive biological information per slide than traditional IHC or IF assays. Screen multiple samples per slide with whole slide scanning or maximize the number of samples per slide with a Tissue Microarray (TMA). Work with a variety of sample types including whole tissue sections and organoids.
Analyze expression of the human whole transcriptome and IO proteome from the same slide
Be the first to discover new biology and novel multiomic biomarkers by utilizing our Spatial Proteogenomics workflow to profile the expression of the human transcriptome and 570+ proteins simultaneously from the same slide. Updated probe chemistry for GeoMx IPA enables same-slide co-detection of RNA and protein for the same sequencing depth and cost as separate detection with serial sections.
IPA Assay Performance Remains Consistent from IPA alone to IPA+WTA
See What 570+ Proteins on One Slide Looks Like
The GeoMx IO Proteome Atlas (IPA) is designed to provide ultra-high plex proteomics data for comprehensive IO research. All panel antibodies were validated through IHC and a host of other orthogonal single plex methods by Abcam, as well as in multiplex by NanoString. Multiplex validation was completed using FDA-approved TMAs across 77 normal human cores representing 29 tissue types and 54 tumor human cores representing 26 tissue types. All panel antibodies were additionally validated in multiplex across 90+ human cell lines for specificity and sensitivity.
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