Masthead

nCounter® Inflammation Panel

Masthead

Helping Your Research

Studying the early inflammatory response is fundamental to understanding the immune response and treating disease. The nCounter® Inflammation Panel lets you perform multiplex gene expression analysis on human or mouse samples with more than 200 genes focused on the study of inflammation. These genes represent a broad range of relevant pathways related to inflammation that include apoptosis, EGF, interleukin signaling, Ras, T cell receptor, and Toll-like receptor signaling. Panel highlights include: 

  • Content useful for the study of asthma, allergy, arthritis, and neurological-related inflammation 
  • Coverage of anti-inflammatory drugs that modulate the inflammatory response 
  • Overlapping coverage between Human and Mouse panels for direct species comparison 
  • Customizable with up to 55 additional user-defined genes with the Panel Plus option

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Publications

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Digital Spatial Profiling Reveals Functional Shift of Enterochromaffin Cell in Patients With Ulcerative Colitis.

As a major component of the enteroendocrine system, enterochromaffin (EC) cells play a key role in ulcerative colitis (UC). However, the scarcity of EC cells has limited the investigation of their function.

PSMA-targeting TGFbeta-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial.

Chimeric antigen receptor (CAR) T cells have demonstrated promising efficacy, particularly in hematologic malignancies. One challenge regarding CAR T cells in solid tumors is the immunosuppressive tumor microenvironment (TME), characterized by high levels of multiple inhibitory factors, including transforming growth factor (TGF)-beta.

Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer.

Purpose: Cancer-associated fibroblasts (CAF) have been implicated as potential mediators of checkpoint immunotherapy response. However, the extensive heterogeneity of these cells has precluded rigorous understanding of their immunoregulatory role in the tumor microenvironment.

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