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nCounter® Host Response Panel

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Helping Your Research

Understanding the complex interplay between a pathogen and the host response is important to developing effective vaccines and therapeutics to fight infectious disease.  The nCounter® Host Response Panel helps researchers study the phases and progression of infection across the major components of the human or mouse host response with pathogen-agnostic content optimized for blood but suitable for all sample types. The panel was specifically developed for understanding the complexities of the immune response to infectious disease, including COVID-19.

How it Works

Host Response Panel
Biological Framework of the Host Response Panel
Panel Customization
Viral Panel Plus Menu
Host Response Panel

The Host Response Panel helps rapidly advance knowledge of emerging infectious disease with experiments that take minutes to set-up and get you results in less than 24 hours.

  • Study the five elements of the host response in human or mouse samples
    • Host Susceptibility
    • Interferon Response
    • Innate Immune Cell Activation
    • Adaptive Immune Response
    • Homeostasis
  • Profile 785 genes in human or mouse genes across 50+ pathways
  • Detect the presence of a pathogen and evaluate organ-specific tissue damage with a Panel Plus spike-in of up to 55 genes
  • Develop signatures of host response dynamics
  • Identify and validate biomarkers for disease severity
  • Evaluate the effect of vaccines & therapies
Get off-the-shelf data analysis and publication-ready figures with nSolver™ Analysis Software
Biological Framework of the Host Response Panel

 

Panel Customization

Customize your research project by adding tissue or pathogen-specific probes to the Host Response Panel with a 55-gene Panel Plus. Add the off-the-shelf 20-gene Coronavirus Panel Plus to study SARS-CoV-2 and other coronaviruses or build your own Panel Plus gene list with transcripts specific for different tissue types. Mix and match transcripts from the pathogen of your choice and additional host tissue markers to add a Panel Plus to the Host Response Panel for studying the pathogenesis of various infectious diseases. Check out the Human or Mouse Host Response Tissue Gene Lists to see which genes to add as a Panel Plus spike-in to study the effect of infectious disease on different organs.

Viral Panel Plus Menu

Add up to 55 viral probes from any specific pathogen or combination of pathogens to the Host Response Panel.  The Viral Panel Plus Menu is a list of pre-designed Research Use Only probes for eight viruses associated with chronic disease and/or cancer.  Probes were designed to cover as many sequences as possible while at the same time ensuring sensitivity, specificity, and breadth of coverage.  Custom probes can be designed to viruses and other pathogens not covered in this list – please contact bioinformatics for more information.

Panel Selection Tool

Find the gene expression panel for your research with easy to use panel pro

Find Your Panel

Product Information

Pathway Annotations
Immune Checkpoint Coverage
NHP Compatibility
Immune Cell Profiling
Product Specifications
Catalog Information
Pathway Annotations
Immune Checkpoint Coverage

Take advantage of comprehensive coverage of the most relevant immune checkpoints to study modulation of the host immune response and subsequent inflammatory cascade.

NHP Compatibility

Probes included in the Human Host Response Panel have high homology to non-human primates (NHPs), allowing for seamless comparative infectious disease research as well as preclinical studies. Percent identity is used to estimate likelihood of the probe functioning on non-human primate targets. Additional comparisons with other NHP species are available upon request.

Immune Cell Profiling

Genes included in the Host Response Panel provide unique cell profiling data to measure the relative abundance of 14 different immune cell types. The table below summarizes the genes included in each cell type signature, as qualified through biostatistical approaches and selected literature in the field

Product Specifications
Catalog Information

Related Resources

See All Resources
Product Bulletin Host Response Panel – Product Bulletin
Webinar Investigating the Host Response to SARS-CoV-2
Poster Spatially resolving the host immune-epithelial landscape in lung tissue from patients infected with SARS-CoV-2 with proteomic and whole transcriptomic profiling – AGBT 2021
Blog The Global Challenge

Publications

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Idelalisib inhibits experimental proliferative vitroretinopathy.

Proliferative vitreoretinopathy (PVR) is a fibrotic eye disease that develops after rhegmatogenous retinal detachment surgery and open-globe traumatic injury. Idelalisib is a specific inhibitor of phosphoinositide 3-kinase (PI3K) δ.

Comparative spatial transcriptomic and single-cell analyses of human nail units and hair follicles demonstrate transcriptional similarities between the onychodermis and follicular dermal papilla.

The nail unit and hair follicle are both hard keratin-producing organs that share various biological features. Here we used a Digital Spatial Profiling (DSP) and single cell RNA sequencing (scRNA-seq) to define a spatially resolved expression profile of the human nail unit and hair follicle.

Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung Disease.

Rationale: The incidence and sites of mucus accumulation, and molecular regulation of mucin gene expression, in COVID-19 lung disease have not been reported. Objectives: Characterize incidence of mucus accumulation and the mechanisms mediating mucin hypersecretion in COVID-19 lung disease.

Skysphere

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