
Category: CosMx SMI
May 31, 2023 / Biomark Res
Single-cell technologies in multiple myeloma: new insights into disease pathogenesis and translational implications
Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of plasma cells. Although therapeutic advances have been made to improve clinical outcomes and to prolong patients’ survival in…
May 29, 2023 / Nat Med
Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance
Tumor-infiltrating T cells offer a promising avenue for cancer treatment, yet their states remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 transcriptomes…
May 23, 2023 / Front Oncol
Could the tumor-associated microbiota be the new multi-faceted player in the tumor microenvironment?
Microorganisms have been identified in tumor specimens for over a century. It is only in recent years that tumor-associated microbiota has become a rapidly expanding field. Assessment techniques encompass methods…
May 22, 2023 / Front Oncol
Multiomics technologies for comprehensive tumor microenvironment analysis in triple-negative breast cancer under neoadjuvant chemotherapy
Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes and is characterized by abundant infiltrating immune cells within the microenvironment. As standard care, chemotherapy remains the…
May 1, 2023 / Front Oncol
The promise and challenge of spatial omics in dissecting tumour microenvironment and the role of AI
Growing evidence supports the critical role of tumour microenvironment (TME) in tumour progression, metastases, and treatment response. However, the in-situ interplay among various TME components, particularly between immune and tumour…
March 3, 2023 / Genome Biol
SRTsim: spatial pattern preserving simulations for spatially resolved transcriptomics
Spatially resolved transcriptomics (SRT)-specific computational methods are often developed, tested, validated, and evaluated in silico using simulated data. Unfortunately, existing simulated SRT data are often poorly documented, hard to reproduce,…
December 21, 2022 / Brief Bioinform
spaCI: deciphering spatial cellular communications through adaptive graph model
December 13, 2022 / Genome Biol
Spatial omics technologies at multimodal and single cell/subcellular level
December 10, 2022 / Nat Commun
Spatial-ID: a cell typing method for spatially resolved transcriptomics via transfer learning and spatial embedding
October 6, 2022 / Nat Biotechnol
High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging
September 30, 2022 / Front Microbiol
The impact of single-cell genomics on the field of mycobacterial infection
September 1, 2022 / Comput Struct Biotechnol J