OLD Category: liver disease
January 4, 2024 / J Hepatol
Single-cell and spatial transcriptomics characterisation of the immunological landscape in the healthy and PSC human liver
BACKGROUND: Primary sclerosing cholangitis (PSC) is an immune-mediated cholestatic liver disease characterized by bile retention, biliary tree destruction, and progressive fibrosis leading to end stage liver disease and transplantation. There…
June 6, 2023 / J Hepatol
Morphologic and molecular analysis of liver injury after SARS-CoV-2 vaccination reveals distinct characteristics
Background and Aims: Liver injury after COVID-19 vaccination is very rare and shows clinical and histomorphological similarities with autoimmune hepatitis (AIH). Little is known about the pathophysiology of COVID-19 vaccine-induced…
June 2, 2023 / Sci Rep
Sample size calculation for a NanoString GeoMx spatial transcriptomics experiment to study predictors of fibrosis progression in non-alcoholic fatty liver disease
Sample size calculation for spatial transcriptomics is a novel and understudied research topic. Prior publications focused on powering spatial transcriptomics studies to detect specific cell populations or spatially variable expression…
May 18, 2023 / Aging (Albany NY)
Senescence and senotherapies in biliary atresia and biliary cirrhosis
Background: Premature senescence occurs in adult hepatobiliary diseases and worsens the prognosis through deleterious liver remodeling and hepatic dysfunction. Senescence might also arises in biliary atresia (BA), the first cause…
November 21, 2022 / JHEP Reports
Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease
January 17, 2022 / Front Cell Infect Microbiol
Elucidating spatially-resolved changes in host signaling during Plasmodium liver-stage infection
November 18, 2021 / Cell Death Dis
Molecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver
October 6, 2021 / J Pathol