OLD Category: neurobiology

September 11, 2023 / Biomed Pharmacother

  • Song G, Plumlee P, Ahn JY, Wong ST, Zhao H
The blood-brain barrier (BBB) plays a critical role in determining the effectiveness of systemic treatments for brain diseases. Over the years, several innovative approaches in BBB opening and drug delivery…
September 1, 2023 / Int J Mol Sci

  • Kremsky I, Ali S, Stanbouly S, Holley J, Justinen S, Pecaut M, Crapo J, Mao X
The demands of deep space pose a health risk to the central nervous system that has long been a concern when sending humans to space. While little is known about…
August 16, 2023 / Nat Commun

  • Freitas-Andrade M, Comin CH, Van Dyken P, Ouellette J, Raman-Nair J, Blakeley N, Liu QY, Leclerc S, Pan Y, Liu Z, Carrier M, Thakur K, Savard A, Rurak GM, Tremblay MÈ, Salmaso N, da F Costa L, Coppola G, Lacoste B
Astrocytes are intimately linked with brain blood vessels, an essential relationship for neuronal function. However, astroglial factors driving these physical and functional associations during postnatal brain development have yet to…
August 11, 2023 / Neurobiol Dis

  • Montillot C, Skutunova E, Ayushma, Dubied M, Lahmar A, Nguyen S, Peerally B, Prin F, Duffourd Y, Thauvin-Robinet C, Duplomb L, Wang H, Ansar M, Faivre L, Navarro N, Minocha S, Collins SC, Yalcin B
The vacuolar protein sorting-associated protein 13B (VPS13B) is a large and highly conserved protein. Disruption of VPS13B causes the autosomal recessive Cohen syndrome, a rare disorder characterized by microcephaly and…
August 8, 2023 / Mol Cell Endocrinol

  • Marinello WP, Gillera SEA, Han Y, Richardson JR, St Armour G, Horman BM, Patisaul HB
Gestational flame retardant (FR) exposure has been linked to heightened risk of neurodevelopmental disorders, but the mechanisms remain largely unknown. Historically, toxicologists have relied on traditional, inbred rodent models, yet…
July 10, 2023 / NPJ Regen Med

  • Siddiqui T, Cosacak MI, Popova S, Bhattarai P, Yilmaz E, Lee AJ, Min Y, Wang X, Allen M, İş Ö, Atasavum ZT, Rodriguez-Muela N, Vardarajan BN, Flaherty D, Teich AF, Santa-Maria I, Freudenberg U, Werner C, Tosto G, Mayeux R, Ertekin-Taner N, Kizil C
Neurogenesis, crucial for brain resilience, is reduced in Alzheimer's disease (AD) that induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring neurogenesis could counteract neurodegenerative pathology. However,…
July 10, 2023 / JCI Insight

  • Alban TJ, Grabowski MM, Otvos B, Bayik D, Wang W, Zalavadia A, Makarov V, Troike K, McGraw M, Rabljenovic A, Lauko A, Neumann C, Roversi G, Waite KA, Cioffi G, Patil N, Tran TT, McCortney K, Steffens A, Diaz CM, Brown JM, Egan KM, Horbinski CM, Barnholtz-Sloan JS, Rajappa P, Vogelbaum MA, Bucala R, Chan TA, Ahluwalia MS, Lathia JD
Intratumoral heterogeneity is a defining hallmark of glioblastoma, driving drug resistance and ultimately recurrence. Many somatic drivers of microenvironmental change have been shown to affect this heterogeneity and, ultimately, the…
June 8, 2023 / J Vet Intern Med

  • Valberg SJ, Willams ZJ, Henry ML, Finno CJ
Background: Shivers in horses is characterized by abnormal hindlimb movement when walking backward and is proposed to be caused by a Purkinje cell (PC) axonopathy based on histopathology. Objectives: Define…
April 27, 2023 / Cancer Res Commun

  • Bonnett SA, Alyssa B Rosenbloom, Giang T Ong, Mark Conner, Aric BE Rininger, Daniel Newhouse, Felicia New, Chi Q. Phan, Saskia Ilcisin, Hiromi Sato, John S Lyssand, Gary Geiss, Joseph M. Beechem
A deeper understanding of complex biological processes, including tumor development and immune response, requires ultra high-plex, spatial interrogation of multiple “omes”. Here we present the development and implementation of a…
April 15, 2023 / Acta Neuropathol Commun

  • Najjary S, Kros JM, de Koning W, Vadgama D, Lila K, Wolf J, Mustafa DAM
Metastases in the brain are the most severe and devastating complication of cancer. The incidence of brain metastasis is increasing. Therefore, the need of finding specific druggable targets for brain…
April 13, 2023 / J Neurotrauma

  • Ravi S, Criado-Marrero M, Barroso D, Braga IM, Bolen M, Rubinovich U, Hery GP, Grudny MM, Koren Iii J, Prokop S, Febo M, Abisambra J
Repetitive mild traumatic brain injuries (rmTBI) are serious trauma events responsible for the development of numerous neurodegenerative disorders. A major challenge in developing diagnostics and treatments for the consequences of…
March 14, 2023 / Cell Rep

  • Walentynowicz KA, Dalit Engelhardt, Simona Cristea, Shreya Yadav, Ugoma Onubogu, Roberto Salatino, Melanie Maerken, Cristina Vincentelli, Aashna Jhaveri, Jacob Geisberg, Thomas O. McDonald, Franziska Michor, Michalina Janiszewska
Glioblastoma (GBM) is the most aggressive brain tumor, with a median survival of ∼15 months. Targeted approaches have not been successful in this tumor type due to the large extent of…