OLD Category: neurobiology
March 7, 2023 / J Alzheimers Dis
Accumulation of pTau231 at the Postsynaptic Density in Early Alzheimer’s Disease
Background:: Phosphorylated cytoplasmic tau inclusions correlate with and precede cognitive deficits in Alzheimer’s disease (AD). However, pathological tau accumulation and relationships to synaptic changes remain unclear. Objective:: To address this,…
March 1, 2023 / Oncoimmunology
Macrophage infiltration promotes regrowth in MYCN-amplified neuroblastoma after chemotherapy
Despite aggressive treatment, the 5-year event-free survival rate for children with high-risk neuroblastoma is
February 16, 2023 / J Anat
The HOPX and BLBP landscape and gliogenic regions in developing human brain
Outer radial glial cells (oRGs) give rise to neurons and glial cells and contribute to cell migration and expansion in developing neocortex. HOPX has been described as a marker of…
January 18, 2023 / Mod Pathol
Highly Multiplexed Spatially Resolved Proteomic and Transcriptional Profiling of the Glioblastoma Microenvironment Using Archived Formalin-Fixed Paraffin-Embedded Specimens
Glioblastoma is a heterogeneous tumor for which effective treatment options are limited and often insufficient. Few studies have examined the intratumoral transcriptional and proteomic heterogeneity of the glioblastoma microenvironment to…
December 20, 2022 / Nat Cancer
A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets
December 16, 2022 / Alzheimers Dement
INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer’s disease
December 13, 2022 / Neurobiol Aging
Signatures for Viral Infection and Inflammation in the Proximal Olfactory System in Familial Alzheimer’s Disease
November 22, 2022 / Cell Rep
Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology
November 21, 2022 / Acta Neuropathol Commun
Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis
November 16, 2022 / Mol Psychiatry
Impact of alcohol exposure on neural development and network formation in human cortical organoids
November 5, 2022 / Brain Commun