Single-Cell Spatial Analysis: Insights and Innovations in Disease Research

In this webinar, three researchers applying single-cell spatial analysis technologies in their labs will discuss how single-cell spatial platforms compare, how advances in plex and technology have impacted single-cell spatial, and how they are maximizing outcomes.

Parambir Dulai, MD,  Associate Professor of Medicine in the Division of Gastroenterology and Hepatology at Northwestern University, will discuss his work in Inflammatory Bowel Disease (IBD), an immune-mediated disorder of the intestinal tract. Hypoxia, micro-vascular perfusion, and barrier dysfunction all have contributing roles to play in shaping environmental cues and interactions. In this context, understanding the spatial cell landscape and single-cell interactions are critical for resolving disease mechanisms and guiding drug development. Parambir will outline considerations when utilizing single-cell spatial platforms and highlight the relative strengths of applying these technologies to study IBD.

Nic West, academic lead at the Central Facility for Genomics at Griffith University in Queensland, Australia, will discuss his lab’s work with the CosMx spatial molecular imager. The ability to explore numerous cell types and pathways in spatial context and at sub-cellular resolution with the platform has led to broad interest across biomedical science. Continual advances have equipped scientists to address a nearly limitless number of biological questions. West will examine key technical aspects and considerations of the CosMx sample workflow and data analysis that the lab has found important for maximizing insights into the biology of disease.

The discussion will be moderated by Arutha Kulasinghe, senior research fellow and lead for the Clinical-oMx Lab at the University of Queensland.