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Neuropathology Panel

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Helping Your Research

Biomarker discovery and signature development are essential for identification of novel therapies and for earlier detection and development of therapies for neurodegenerative disorders like Alzheimer’s Disease (AD), Parkinson’s Disease (PD), and Amyotrophic Lateral Sclerosis (ALS). The nCounter Neuropathology Panel helps perform comprehensive multiplex gene expression analysis in human or mouse samples with genes involved in six fundamental themes of neurodegeneration: neurotransmission, neuron-glia interaction, neuroplasticity, cell structure integrity, neuroinflammation, and metabolism.

  • Developed for research of Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Huntington’s Disease, and other neurological disorders
  • Includes unique cell typing feature for measuring the abundance of five important CNS cell types, including neurons, astrocytes, microglia, oligodendrocytes, and endothelial cells
Neuropathology Panel

How It Works

nCounter Neuropathology Panels utilize NanoString’s unique barcoding technology and the nCounter Analysis System to help accelerate your research.

01:

Screen 770 genes specific for neurodegeneration

02:

Comprehensively Assess 23 pathways

03:

Monitor progression of neurodegeneration

04:

Screen potential therapeutics

05:

Discover biomarkers and develop signatures associated with neurodegeneration

06:

Customize with up to 55 additional user-defined genes with the Panel Plus option

07:

Get data quickly with a streamlined, user-friendly, and efficient workflow with only 15 minutes hands-on time

Panel Selection Tool

Find the gene expression panel for your research with easy to use panel pro

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Product Information

CNS Cell Typing
Functional Annotations
Product Specifications
Catalog Information
CNS Cell Typing

Genes included in the Neuropathology Panels provide unique cell profiling data for measuring the abundance1 of five important cell types including neurons, astrocytes, microglia, oligodendrocytes, and endothelial cells. The table below summarizes each cell type represented in the panels along with the gene content qualified through current literature references.

1Danaher P. et al. Gene expression markers of Tumor Infiltrating Leukocytes JITC 2017

Functional Annotations

Functional annotations for 23 fundamental pathways and processes were assigned across all genes in the Neuropathology Panels allowing for a practical view of important aspects of the onset and progression of neurodegenerative disease.

Product Specifications
Catalog Information

Related Resources

See All Resources
Product Bulletin nCounter Neuropathology Panel – Product Bulletin
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Flyer Explore the Biology of Neuropathic Pain with nCounter Gene Expression Analysis
Flyer Custom Solutions Neuropathic Pain – Flyer
Blog Advancing Neuroscience Gene Expression Research

Publications

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Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling.

Clinical symptoms correlate with underlying neurodegenerative changes in the vast majority of people. However, an intriguing group of individuals demonstrate neuropathologic changes consistent with Alzheimer disease (AD) yet remain cognitively normal (termed “resilient”).

Spatial molecular profiling of a central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency (CNS LGDIT-INI1) featuring a high-grade AT/RT component.

Key points: – diffusely infiltrative low-grade tumour with SMARCB1/INI1-deficiency (CNS LGDIT-INI1) has been proposed as a new entity – we report the first case of a child with a CNS LGDIT-INI1 with a high-grade AT/RT component at the time of initial surgery – methylation profiles of both the low- and the high-grade component yielded high similarity with ATRT-MYC – spatial transcriptome analyses showed upregulation of glioneuronal markers in the low grade component underlining the concept of diffuse infiltrative behaviour of CNS LGDIT-INI1 – high-grade tumour areas displayed increased translational activity and proliferation as well as MYC pathway activation.

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Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma.

Intraocular medulloepithelioma (IO-MEPL) is a rare embryonal ocular neoplasm, prevalently occurring in children. IO-MEPLs share histomorphological features with CNS embryonal tumors with multilayered rosettes (ETMRs), referred to as intracranial medulloepitheliomas.

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