nCounter® Neuroinflammation Panel
Helping Your Research
Neuroinflammation research today requires a broad view of all the underlying aspects of neurological disorders and injury, including an assessment of neurotransmission, neuron-glia interactions, neuroplasticity, cell integrity, neuroinflammation, and metabolism. The nCounter Neuroinflammation Panels support and simplify your neuroinflammation research needs by providing a complete view of the complex interplay between the immune system and the Central Nervous System (CNS). These panels deliver a comprehensive evaluation of the pathways, processes, and cell types that are involved in neuroinflammation. Product highlights include:
- Gene expression profiling of neuroimmune interactions
- The study of drug treatment response and signature generation
- Biomarker characterization
- Research of neurodegenerative disease, traumatic brain injury, psychiatric disorders, neuropathic pain, CNS infection, and others
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Product Information
Genes included in the Neuroinflammation Panels provide unique cell profiling data for measuring the relative abundance of 5 CNS and 14 peripheral immune cell types in a single sample1. The table below summarizes each cell type represented by gene content in the panel qualified through biostatistical approaches and selected literature in the field of neuroinflammation research.
1Danaher P. et al. Gene expression markers of Tumor Infiltrating Leukocytes JITC 2017
Functional annotations for 23 pathways and processes were assigned across the genes in the Neuroinflammation Panels. The 23 pathways and processes represent three core themes of neuroinflammation: immunity and inflammation, neurobiology and neuropathology, and metabolism and stress.
The role of innate immunity in many neurological disorders is now widely accepted in the research world although the relative contributions of these processes to the progression and/or amelioration of these diseases is incompletely understood. Several key processes and pathways are assessed in this panel to provide a comprehensive view of the immune and inflammatory response in the nervous system.
Neuropathology research today requires a broad view of all the underlying aspects of neurological disorders and injury, including an assessment of neurotransmission, neuron-glia interactions, neuroplasticity, cell integrity, neuroinflammation, and metabolism. There are 13 pathways and processes included in this panel to evaluate the impact of neuroinflammation and immune actions in the nervous system on neuropathology.
Metabolic dysfunction and stress have been shown to influence brain activity and disrupt CNS homeostasis and cognitive function by adopting neurotoxic functions. The genes selected for this panel are designed to assess important aspects of metabolism and stress that are known to impact neuroinflammation.
Related Resources
Publications
The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment.
The mechanisms underlying how urban air pollution affects Alzheimer’s disease (AD) are largely unknown. Ozone (O3) is a reactive gas component of air pollution linked to increased AD risk, but is confined to the respiratory tract after inhalation, implicating the peripheral immune response to air pollution in AD neuropathology.
Intratarget Microdosing for Deep Phenotyping of Multiple Drug Effects in the Live Brain.
A main impediment to effective development of new therapeutics for central nervous system disorders, and for the in vivo testing of biological hypotheses in the brain, is the ability to rapidly measure the effect of novel agents and treatment combinations on the pathophysiology of native brain tissue. We have developed a miniaturized implantable microdevice (IMD) platform, optimized for direct stereotactic insertion into the brain, which enables the simultaneous measurement of multiple drug effects on the native brain tissue in situ.
Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling.
Clinical symptoms correlate with underlying neurodegenerative changes in the vast majority of people. However, an intriguing group of individuals demonstrate neuropathologic changes consistent with Alzheimer disease (AD) yet remain cognitively normal (termed “resilient”).
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