nCounter®
PanCancer Progression Panel

Helping Your Research

Cancer progression involves multiple processes and mechanisms that are highly interconnected. The nCounter PanCancer Progression Panel lets you perform multiplex gene expression analysis with 770 genes from each step in the cancer progression process including: angiogenesis, extracellular matrix remodeling (ECM), epithelial-to-mesenchymal transition (EMT) and metastasis. 

  • Comprehensive gene expression analysis of cancer progression 
  • Quantify gene expression of metastatic growth and suppressor genes 
  • Rapidly and easily screen samples for biomarker discovery or drug mechanism of action to support your research 
  • Customizable with up to 55 additional user-defined genes with Panel Plus option 
  • 3D-enabled for multi-analyte analysis with Vantage 3D™ Assays

Inspired by systems biology approaches to cancer research, NanoString’s 360 Series Panel Collection gives you a 360° view of gene expression by combining carefully-curated content involved in the biology of the tumor, microenvironment, and the immune response into a single holistic assay. Each panel contains the 18-gene Tumor Inflammation Signature (TIS) that measures a peripherally-suppressed, adaptive immune response and has been shown to correlate with response to checkpoint inhibitors.

How It Works

Progression Panel Gene Coverage

The following is a pictorial description of the processes and key genes included in the PanCancer Progression Panel

Panel Selection Tool

Find the gene expression panel for your research with easy to use panel pro

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Product Information

Specifications
Catalog Information
Product Comparison
Specifications
Catalog Information
Product Comparison

360 Series Product Comparison

Fully-annotated gene lists in Excel format are available for each of the 360 Panels. The table below compares the biology coverage of the 360 Panels across the tumor, microenvironment, and the immune response to that of the PanCancer Panels Collection.

Related Resources

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Product Bulletin Hallmarks of Cancer – Product Bulletin
Supplement Hallmarks of Cancer Supplement
Hallmarks of Cancer: New Dimensions
Whitepaper Multiplexed Cancer Progression Analysis – Whitepaper

Publications

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The prognostic value and molecular properties of tertiary lymphoid structures in oesophageal squamous cell carcinoma.

Background: Tertiary lymphoid structures (TLSs) play key roles in tumour adaptive immunity. However, the prognostic value and molecular properties of TLSs in oesophageal squamous cell carcinoma (ESCC) patients have not been studied.

Location matters: LAG3 levels are lower in renal cell carcinoma metastatic sites compared to primary tumors, and expression at metastatic sites only may have prognostic importance.

While great strides have been made in the treatment of advanced renal cell carcinoma (RCC) with the emergence of immune checkpoint inhibitors (ICIs) and VEGFR-targeting drugs, sizable proportions of patients still do not respond to upfront therapy and long-term responses only occur in a minority of patients. There is therefore a great need for the development of better predictors of response and an increased understanding of mechanisms of resistance to these therapies.

The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis.

Brain metastases (BrMs) are a common occurrence in lung cancer with a dismal outcome. To understand the mechanism of metastasis to inform prognosis and treatment, here we analyze primary and metastasized tumor specimens from 44 non-small cell lung cancer patients by spatial RNA sequencing, affording a whole transcriptome map of metastasis resolved with morphological markers for the tumor core, tumor immune microenvironment (TIME), and tumor brain microenvironment (TBME).

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