NanoString Blog
Category: CosMx SMI
CosMx SMI
Tips to optimize sample prep for highly autofluorescent samples on CosMx® SMI
The CosMx® Spatial Molecular Imager (SMI) instrument performs fluorescent imaging to read out in-situ hybridized fluorescent reporters which uniquely identify RNA transcripts. The presence of tissue autofluorescence background may reduce…
CosMx SMI
Moving Beyond scRNA-seq: The Power of CosMx Whole Transcriptome
Single-cell RNA sequencing (scRNA-seq) has transformed molecular biology by enabling high-throughput transcriptional profiling at cellular resolution. But as powerful as scRNA-seq is, it comes with trade-offs: loss of spatial information,…
CosMx SMI
Revealing Spatial Biology at Whole-Transcriptome Scale: Introducing the CosMx® Human Whole Transcriptome Panel
Learn how CosMx WTX brings whole-transcriptome coverage to every cell in FFPE tissues, uncovering truly groundbreaking spatial biology.
CosMx SMI
Tips when performing CosMx™ data analysis with AtoMx SIP
Single-cell spatial biology opens doors to unprecedented scientific questions requiring the development of new computational workflows and approaches to analyze and interpret data. Whether you are new to single-cell spatial…
CosMx SMI
Tips when Generating Single-Cell Spatial Data: Post Run H&E and Antibody Staining
We are excited to share the third installment of tips for successful CosMx™ SMI single-cell spatial runs at 1000-plex. Our first installment of tips focused on data by tissue and…
CosMx SMI
Tips When Generating Single-Cell Spatial Data: Sample Selection
We are excited to share the second installment of tips for successful CosMx™ SMI single-cell spatial runs at 1000-plex. Our first installment of tips focused on data by tissue and…
CosMx SMI
Top 3 Tips for Successful CosMx™ SMI Single-cell Spatial Runs at 1000 plex
We are excited to share insights and recommendations to enhance your experience with CosMx™ SMI 1000-plex RNA assays. The quality of single-cell spatial data is influenced by various factors, and…
CosMx SMI Spatial Biology
Complex Cell Segmentation and Its Significance in Spatial Biology
In research, scientists are continually pushing boundaries to gain deeper insights into biology, medicine, and drug discovery. Single-cell spatial imaging has emerged as a powerful technology in the field of…
CosMx SMI GeoMx DSP
What does nTPM mean in the protein atlas?
The goal of the Human Protein Atlas (HPA) project is to map all human proteins in cells, tissues, and organs. Further, it aims to annotate the function and spatial distribution of…
CosMx SMI
What are some examples of cell signals?
Cell signaling is one of my absolute favorite topics in molecular biology. In fact, a lecture on cell signaling during my sophomore year of college was the reason why I…
CosMx SMI
What are some examples of cell to cell interactions?
The coordination of 37.2 trillion cells is required for our bodies to function, but it can be difficult enough to coordinate a classroom of thirty students. How then are so…
CosMx SMI
Common questions in molecular biology: What is the importance of cell interactions?
Can you imagine if a cell could send an email? Or put in a work request? Think of it: Dear Immune System, I am infected by a virus. Please send…