NanoString Blog

Category: CosMx SMI

CosMx tissue image

CosMx SMI

Tips when performing CosMx™ data analysis with AtoMx SIP

Single-cell spatial biology opens doors to unprecedented scientific questions requiring the development of new computational workflows and approaches to analyze and interpret data. Whether you are new to single-cell spatial…

Bruker Spatial Biology / October 3, 2024
CosMx tissue image

CosMx SMI

Tips when Generating Single-Cell Spatial Data: Post Run H&E and Antibody Staining

We are excited to share the third installment of tips for successful CosMx™ SMI single-cell spatial runs at 1000-plex. Our first installment of tips focused on data by tissue and…

NanoString / May 9, 2024
CosMx tissue image

CosMx SMI

Tips When Generating Single-Cell Spatial Data: Sample Selection 

We are excited to share the second installment of tips for successful CosMx™ SMI single-cell spatial runs at 1000-plex. Our first installment of tips focused on data by tissue and…

NanoString / February 13, 2024
CosMx tissue image

CosMx SMI

Top 3 Tips for Successful CosMx™ SMI Single-cell Spatial Runs at 1000 plex

We are excited to share insights and recommendations to enhance your experience with CosMx™ SMI 1000-plex RNA assays. The quality of single-cell spatial data is influenced by various factors, and…

NanoString / December 13, 2023

CosMx SMI Spatial Biology

Complex Cell Segmentation and Its Significance in Spatial Biology

In research, scientists are continually pushing boundaries to gain deeper insights into biology, medicine, and drug discovery. Single-cell spatial imaging has emerged as a powerful technology in the field of…

Lisa Kessler / October 30, 2023

CosMx SMI GeoMx DSP

What does nTPM mean in the protein atlas?

The goal of the Human Protein Atlas (HPA) project is to map all human proteins in cells, tissues, and organs.  Further, it aims to annotate the function and spatial distribution of…

Nirupama Deshpande / July 3, 2023
Green-outlined cells on a dark background, with pink/purple splotches in each cell

CosMx SMI

What are some examples of cell signals?

Cell signaling is one of my absolute favorite topics in molecular biology. In fact, a lecture on cell signaling during my sophomore year of college was the reason why I…

Geoffrey Hummelke / June 18, 2023

CosMx SMI

What are some examples of cell to cell interactions?

The coordination of 37.2 trillion cells is required for our bodies to function, but it can be difficult enough to coordinate a classroom of thirty students. How then are so…

Geoffrey Hummelke / June 17, 2023

CosMx SMI

Common questions in molecular biology: What is the importance of cell interactions?

Can you imagine if a cell could send an email? Or put in a work request? Think of it: Dear Immune System, I am infected by a virus. Please send…

Geoffrey Hummelke / June 16, 2023

CosMx SMI

Common questions in molecular biology: What are types of cell-cell interactions?

Much like bees or ants, cells are inherently social. Also like various hive-based insects, the social nature of the interactions are important for dictating function and well being of the…

Geoffrey Hummelke / June 15, 2023

CosMx SMI

Common questions in molecular biology: Why do we need biomarkers?

What does it mean to be healthy? If you go in for a regular wellness appointment at the doctor’s office, how does the doctor assess if you are healthy? Wellness…

Geoffrey Hummelke / June 14, 2023
Green-outlined cells on a dark background, with pink/purple splotches in each cell

CosMx SMI

Common questions in molecular biology: What can biomarkers tell us?

As we go about our day, we are surrounded by indicators. Our clocks tell us the time. Ovens will reveal their current temperatures and alert us when they’ve reached their…

Geoffrey Hummelke / June 13, 2023